The Role of HLA-DRB1 Gene Polymorphism and Anti HLA–G In The Development Of Acute Leukemia In Egyptian Patients And Their Effect In Disease Resistance Or Susceptibility.

 this work aims to investigate role of HLA-DRB1 alleles and anti-HLA-G in the development of acute leukemia in Egypt, patients and methods, (40) patients with acute leukemia aged from 4 to 60 years (23 male and 17 female), and 20 healthy subjects of the same age and sex as a control, ethical review board approved the work , , results there was an allelic association between HLA-DRB1,and AML, difference between DRB1*13 and was significant p = 0.006 , p = 0.016 respectively, HLA-DRB1*01 not detected in any AML patients in relation to ALL patients, the HLA-DRB1*13 show high frequency in controls in relative to AML patient (P = 0.006 , 0.001), anti-HLA-G showed no significant values in leukemic patients and control. Conclusion, HLA-DRB1*13, and HLA-DRB1*15 alleles were protective while HLA-DRB*06 and –DRB1*14 were predisposing factor for AML .