Rate constants for base hydrolysis of bis(naphthylidene isoleucinate)iron (II) (nili),
bis(naphthylidene leucinate)iron(II) (nli), bis(naphthylidene serinate)iron(II) (nsi), bis
(salicylidene isoleucinate)iron(II) (sili), (salicylidene leucinate)iron(II) (sli), bis(salicylidene
methioninate)iron(II) (smi), and (salicylidene tryptophanate)iron(II) (sti) have
been reported in different binary aqueous mixtures at 298 K. The observed reactivity
trends are discussed in terms of the hydrophilic and hydrophobic forms of the complexes
investigated, as well as the transfer chemical potentials of hydroxide ion and the complex.
Both the solvent–solute and solvent–solvent interactions have been considered. The
hydrophobic character of the complexes studied was manifested by enhancing the rate
of base hydrolysis at the initial addition of the different cosolvents; further addition
led mostly to a decrease in reactivity, but, in some cases, the greater destabilization
of OH¡ ion by added DMSO and acetone increases the rate of base hydrolysis. The
modified Savage–Wood equation, based on the principle of group additivity,was applied
to estimate the observed kinetic medium effects.