Background
Obesity is a risk factor for obesity-related disorders such as type 2 diabetes mellitus,
vascular disease, osteoarthritis, sleep apnea, and malignancy. Obesity cohinder
the individual work capacity, and the cost for managing obesity complications is
high.
Objective
The objective of this research was to study the role of pancreatic polypeptide family
including neuropeptide Y and peptide tyrosine tyrosine (PYY) in obesity development and its metabolic changes.
Materials and methods
Twenty-seven adult female albino rats of a local strain were randomized into three
equal groups for 5 weeks: sham-operated group, ovariectomized nontreated group,
and ovariectomized treated group received PYY3–36 at a dose of 50 μg/kg, by
intraperitoneal injection twice daily during the fifth week.
Results
Peripheral PYY3–36 administration reduces food intake, body weight gain, and
serum glucose in ovariectomized obese female rats.
Conclusion
PYY system may offer a new therapeutic strategy for obesity management and its
metabolic abnormalities.