Alopecia areata is a common  cause  of nonscarring alopecia  that occurs  in a patchy,  confluent, or diffuse pattern. Dermoscopy is a noninvasive technique for the clinical diagnosis of many skin diseases.  Topical  minoxidil solution  5% and  platelet  rich plasma  are  important modalities  used  in treatment of alopecia areata. We  aimed  to evaluate the efficacy of PRP versus  topical minoxidil 5% in the  treatment of AA by clinical evaluation  and  trichoscopic  examination.  Ninety  patients were  allocated into three groups; the first was treated with topical minoxidil 5% solution, the second with platelets rich plasma injections, and the third with placebo. Diagnosis and follow up were done  by serial digital camera  photography of lesions and  dermoscopic scan  before  and  every  1 month  after  treatment for 3 months. Patients treated with minoxidil 5% and platelets rich plasma both have significant hair growth  than placebo  (p < .05). Patients treated with platelets rich plasma had an earlier response in the form of hair regrowth, reduction in short vellus hair and dystrophic hair unlike patients treated with minoxidil and control (p < .05). In conclusion, platelets rich plasma is more effective in the treatment of alopecia areata than topical minoxidil 5% as evaluated by clinical and trichoscopic examination.