Background: Hepatitis C virus, has been associated with a wide variety of extrahepatic manifestations (EHM) in the natural history of the disease. Lichen planus (LP) has also been reported in association with the hepatitis C virus. Objective is to determine the frequency of HCV in patients with LP in Sohag University Hospital. Patients and methods: The study was carried out in Sohag University Hospital in Clinical Pathology Department and Dermatology Venereology Department from October 2009 to April 2010, on 70 patients with LP (34 males, 36 females) their age ranged from 25 to 80 years old, and 20 patients (11 males, 9 females) their age ranged from 22 to70 years old as a control group with other dermatological manifestations. Patients were recruited from the out patient clinic of dermatology department, full history, clinical examination, biopsy in some cases to confirm the diagnosis of LP and laboratory investigations for anti-HCV detection, liver function tests were done. Results: There was insignificant difference between LP group and the control group regarding the age or the sex (p = 0.176). There was a highly significant increase in HCV infection between LP group (p = 0.000), a significant increase in HCV infection among the old age patients (p = 0.008) was found, HCV infection and duration of LP showed a significant correlation (p = 0.022), There was an increase in aspartate aminotransferase (AST) in actenic LP patients and mucous LP patients compared with those of classic type (p = 0.028).Conclusion: A possible relationship between LP and HCV, thus, it seems that the HCV antibody test is necessarily required for LP patients.