The Temple of Medamud is one of the most valuable temples at Luxor that is currently threatened by agricultural expansion and urban encroachment since the last fourty years. The temple is currently threate sewage water from the increasingly urban encroachment were different forms of deterioration are noted represented by salt efflorescence on the temple remains, soil salinization on the ground, collapse of mora of structure, stone brittleness, and bleeding of foundation stones. It is recommended to take immediate actions to protect the Temple of Medamud from further deterioration and losing its value. Using capillary buffer zone is strongly recommended. Restricting irrigation practices, using modern irrigation methods, lining the irrigation canals, and improving the drainage system in the study area are considered primitive clues for mitigating the impact of groundwater rise and deterioration of the temple remains.