Objectives: Varicocele is the most common cause of male infer- tility. It affects spermatogenesis by multiple theories, the most recent is by increasing the levels of reactive oxygen species. Medical treatment in the form of tamoxifen, anti-oxidant (Zinc) and MPFF (Micronised puriﬁed ﬂavonoid fractions), may improve sper- matogenesis and semen parameters in patients with varicocele.
Our study aims to show the efﬁcacy of medical treatment on semen parameters and varicocele degree in varicocele patients with oligoasthenoteratozoospermia (OAT).
Material and Methods: This study included 60 male patients with varicocele and OAT. Clinical and radiological assessment of varicocele and WHO semen analysis have been performed before and 3 months after medical treatment. Patients were treated with Tamoxifen 20 mg / day, Oral Zinc and (Diosmin 450 mg and Hesperidin 50 mg) 3 time / day for 3 months.
Results: There was a statistically signiﬁcant increase in sperm concentration, progressive sperm motility, total sperm motility and sperm morphology (p ¼.009, .005, .020, 0.001) after 3 months of treatment. No signiﬁcant changes in varicocele degree and veins diameter after treatment.
Conclusion: Medical treatment with Tamoxifen 20 mg / day, Oral Zinc and (Diosmin 450 mg and Hesperidin 50 mg) 3 time / day for 3 months has a signiﬁcant beneﬁcial effect on sperm concentration, Progressive motility, morphology and total motility. It has no signiﬁcant effect on decreasing vein diameter of varicocele or presence of reﬂux.