Survivin mutation and wild type P53 tumor suppressor gene expression in Egyptian patients with acute leukemia: Hasnaa A. Abo-Elwafa, Fadia M. Attia, Amany M Hesen, Amany ElBaz, Clinical Pathology Department, Sohag University, Clinical Pathology Department and Physiology Department Suez canal university. The Egyptian Journal of Hematology, Vol. (35), No.(4), p387-390 September 2010.
Abstract: Survivin a member of the inhibitors of apoptosis family, is one of the most frequent up regulated transcripts in solid tumor, wild type P53 tumor suppressor gene is involved in regulation of surviving expression in leukemic cells. Aims to assess the expression of wild P53 tumor suppressor gene and surviving expression in BM samples of adults patients with acute leukemia before chemotherapy.
Key words: Survivin, Wild P53, acute leukemia