Background Dermoscopy is a simple and inexpensive diagnostic technique that permits the visualization of morphologic features that are not visible to the naked eye, forming a link between clinical dermatology and microscopic dermatopathology. For many years, skin biopsy was considered the only definite diagnostic tool that confirms or excludes the clinical diagnosis. Skin biopsies are invasive and have many adverse effects and precautions. Objective To evaluate the accuracy of dermoscope in diagnosis of skin tumors and its correlation with clinical and pathological diagnosis. Patients and methods Thirty-four patients who attended Dermatology Clinic at Qena University Hospital from January 2013 to December 2014 were recruited in a nonrandomized prospective study. The inclusion criteria were reported through the following: full history taking, such as (a) name, age, sex, duration of the lesion, onset, progress, and symptoms; (b) previous history of similar lesions or skin cancer; (c) family history of similar lesion or skin cancer; and (d) any recognized changes in the lesion in the past year such as change in size, consistency, hair growth, or bleeding; dermatologic examination, such as (I) type, site, size, shape, color, surface, and border of lesion have been also detected and reported by using of the three-point checklist as a method for differentiation between benign and suspicious lesions and (II) any specific manifestations as tenderness, bleeding, and recurrence have been detected; (III) digital photography has been performed using digital camera (Sony cyber-shot 16.1 mega pixels); dermoscopic findings by using dermoscope (HEINE BETA DELTA 20), and histopathological examination. Results There was an excellent di