This study aimed to assess the role of varicocelectomy in the improvement of premature
ejaculation (PE) in patients with clinical varicoceles and PE. Materials and Methods: In a prospective clinical
study, it conducted on 85 male patients with clinical varicoceles and PE. Those patients were selected from
whom attending the Outpatient Clinics of Andrology and General Surgery at Sohag University Hospital, Upper
Egypt, between February 2015 and May 2016. All patients were subjected to preliminary assessment included
a detailed medical and sexual history and general and genital examination. Patients were treated with open
bilateral subinguinal varicocelectomy under spinal anesthesia. All patients were evaluated before and 6 months
after the varicocelectomy by PE diagnostic tool (PEDT). The intravaginal ejaculatory latency times (IELTs) per
minute and overall sexual satisfaction scores were evaluated before and 6 months after varicocelectomy. All
patients were asked to indicate their sexual satisfaction on a scale of 0–5, with 0 being extremely dissatisfied and
5 being extremely satisfied. Results: The mean scores of the five questions of the PEDT measuring ejaculation
control, frequency of inability of ejaculation control, ejaculation with minimal stimulation, feel of distress, and
interpersonal difficulty owing to PE had statistically significant improvements at 6 months after varicocelectomy.
The mean IELTs per minute and overall sexual satisfaction scores were significantly improved at 6 months after
varicocelectomy. Conclusions: The study concluded that varicocelectomy improve PE in patients with bilateral
clinical varicoceles and PE. Further prospective, controlled studies are needed to provide further characterization
of this potential relationship.