Objectives: To assess the impact of psoriasis on patients' quality of life. Subjects and Methods: Sixty psoriasis patients were selected among attendants of outpatients clinic, Dermatology and Venereology Depettment, Sohag university and 30 healthy age- and sex-matched subjects served as a control. Results: Quality of life of more than /Jalf of psoriasis patients was bad (51. 7%), compared with 13.3% of the control subjects. Younger psoriasis patients tend to have worse quality of life, asof patients aged less than 30 years had bad quality of life compared with 34% of those agedyears or more. Female patients had worse quality of life than male patients. Patients whose course of disease was progressive had worse quality of life than those with sieiionery course. As the psoriasis severity increases, there is a tendency to have worse quality of life. A good quality of life was experienced by 42. 9% of patients with mild psoriasis, 15% of those with mild disease and only 7. 7% of those with severe psoriasis. Conclusions: psoriasis is a psychosomatic disease that significantly affects the quality of patients Its impact is correlated with disease severity and course, for which females and younger patients are most vulnerable. Recommendations: Psorialic patients need an empathic and supportive relationship with their physician.The dermatologist should not focus his attention exclusively on theskin of patients.