Background: Acrylamide (ACR) is a water soluble vinyl monomer that has multiple chemical and industrial applications. Several studies were used to define its side effect on  liver, kidney, brain and erythrocyte which proved that (ACR) increased glutathione-s-transferase and causing oxidative stress. Ascorbic acid is natural antioxidant that prevents the increased production of free radicals induced by oxidative damage to various cellular components. Theaim of work : This  work aimed to  the study the effect of ACR on the jejunum of adult male albino rats and to evaluate the possible  protective role of ascorbic acid. Material and methods: thirty albino rats (2-3 months old) were used in the present study. Their weights ranged from 200-250 grams. The rats were divided into 5 group; Group Ι:  were used as negative control group .Group IIa:  received ACR ,30 ml\kg orally daily for 4weeks  .Group IIb  : received both ACR, 30 ml\kg orally simultaneously with ascorbic acid 400ml \kg. intraperitoneally daily for 4weeks. Group IIIa : received ACR 80 ml\kg orally for 4weeks.Group IIIb :received both ACR 80 ml\kg orally simultaneously with ascorbic acid 400ml \kg. intraperitoneally daily for 4weeks.The jejunum were dissected and processed for histological and immunohistochemical  studies . Results: Dose dependent histopathological changes of The jujenal  villi  and muscuolosa  were observed after ACR treatment  . There were marked  inflammatory cell  infiltrations and vascular congestion in the lamina propria, submucosa and musculosa. There was  increase in the PCNA and AFP positive cells . All these changes could be significantly attenuated by  using ascorbic acid with ACR. Conclusion: Fried food should not  be  used so frequent and if no way to be used ,  it is essential to use  meals containing ascorbic acid .