We have investigated the kinetics of hydroxide ion attack at iron(II) chelates with 5-bromosalicylidene
derivatives of amino acids (alanine, phenylalanine, aspartic acid, histidine, and arginine) in binary aqueous mixed solvents at 298 K. The observed reactivity trends are discussed in connection with the complexes hydrophobicity/hydrophilicity, transfer chemical potentials of hydroxide ion and the complex, and the solvent effects.