Chemotherapy- induced nausea and vomiting are the most undesirable and common side effects of chemotherapy among children undergoing cancer treatment account for 70- 80%. So this study aimed to determine the effect of therapeutic massage on nausea and vomiting among children with leukemia following chemotherapy. A quasi- experimental research design was used to conduct the study. The study was conducted at Pediatric Oncology Department in South Egypt Cancer Institute at Assiut University and Pediatric Oncology Department at Sohag Cancer Center. A convenience sampling of 66 children with leukemia of aging 4- 16 years were divided into two groups study and control group (33 children for each group). Sample was collected for a period of 6 months. Two tools were utilized in the study, Sociodemographic and clinical interview questionnaire was developed to assess data about children and Rhodes Index of Nausea and Vomiting likert Scale was used to assess nausea and vomiting among the studied children. The study revealed that, highly statistical significant difference was found between both groups in relation to frequency, distress and severity of nausea and frequency, duration and severity of vomiting (p= 0.000). Conclusion: Children with leukemia who are receiving therapeutic massage were experiencing less incidence and severity of nausea and vomiting than those who are receiving only the routine hospital care. Recommendations: Encourage health care professionals to use therapeutic massage techniques to reduce chemotherapy induced nausea and vomiting in children.