LUNG TUMORS CLASSIFICATIONS
“Hamartoma”
Carcinomas of the Lung “Lung Cancer”
WHO Classifications of Lung Tumors
Historical aspect
2004 WHO Histological Classification of Tumors of the Lung
WHO Classifications of Lung Tumors, 2015
The most significant changes in this edition compared with 2004
CLASSIFICATION OF LUNG CANCER IN SMALL DIAGNOSTIC SAMPLES AND CYTOLOGY SPECIMENS
LUNG CANCER
INCIDENCE AND CLASSIFICATION
M O R P H O LO G Y
Grossly
Hilar type
Peripheral type
ADENOCARCINOMA
Atypical Adenomatous Hyperplasia (AAH)
Adenocarcinoma In Situ (AIS)
Minimally Invasive Adenocarcinoma (MIA)
Invasive Adenocarcinoma
Grossly
On histological examination
Adenocarcinoma Variants
Squamous Cell Carcinoma (SCC)
Major Changes in Squamous Cell Carcinoma Classification
Grossly
Histologically
Neuroendocrine Tumors
Preinvasive Neuroendocrine Tumors
Invasive Neuroendocrine Tumors
Grossly
Small cell lung carcinomas (SCLCs)
Histologically
Nuclear features are crucial to diagnosis
Typical carcinoid
Atypical carcinoid tumor
Large Cell Carcinoma (LCC)
Histological Grading of Lung Cancer
Mesothelioma
Benign Mesothelioma
Benign multicystic mesothelioma and adenomatoid tumor
Malignant Mesothelioma
Morphologic Features
Grossly
Microscopically
Epithelioid mesotheliomas
Grossly
Microscopically
Sarcomatoid mesotheliomas
Grossly
Microscopically
Biphasic mesotheliomas
Mesothelioma Variants
Well-differentiated papillary mesotheliomas
Deciduoid mesothelioma
Mesothelioma with clear cell features
Mesothelioma with rhabd features
Small cell variant of malignant mesothelioma
Lymphohistiocytoid mesothelioma
Pleomorphic mesothelioma
Desmoplastic mesoth
Histological features
WHO Classifications of Pleural Tumors
Solitary Fibrous Tumor
Grossly
Microscopically
Malignant solitary fibrous tumors
Other Primary Tumors
Mucoepidermoid carcinoma
Synovial sarcoma
Epithelioid hemangioendothelioma and angiosarcoma
Malignant lymphoma involving the pleura
Diffuse large B-cell lymphoma, and follicular lymphoma
Pyothorax-associated lymphoma
Primary effusion lymphoma
Metastatic Tumors
