eman_shalabi

Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط

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Tumors of the Medistinum for Postgraduates of Pathology, Oncology, and Cardiothoracic Surgery

2018-10-02 10:56:32 |

TUMORS OF THE MEDIASTINUM 
THYMOMA AND THYMIC CARCINOMACARCINOMA

Classification of Thymic Tumors

Historically

The descriptive scheme

The scheme based on topographic and morphofunctional characteristics

Müller-Hermelink scheme comprises the following 5 types

The World Health Organization (WHO) Classification of Tumors of the Thymus and other thoracic tumors

 

Thymoma and Thymic Carcinoma

General Features

Thymoma

Location of thymoma

Radiographically

Fine-needle aspiration

Pathologic Features of Thymoma

Grossly

 “Microthymomas”

Microscopically

By electron microscopy

Immunohistochemistry

Classification of Thymoma and Thymic Carcinoma

The subtypes of thymomas included in the WHO classification

Type A Thymoma (Spindle Cell; Medullary)

Type AB Thymoma (Mixed)

Type B1 Thymoma (Lymphocyte-Rich; Lymphocytic; Predominantly Cortical; Organoid)

Type B2 Thymoma (Cortical)

Type B3 Thymoma (Epithelial; Atypical; Squamoid; Well-Differentiated Thymic Carcinoma)

Rare subtypes of thymoma that do not easily fit into the A-B nomenclature include

Micronodular thymoma

Metaplastic thymoma

Microscopic thymoma (nodular hyperplasia)

Cytology

Limitations of the procedure

 

Thymic Carcinoma

Thymic tumor

Thymic Carcinoma

Differences from other conventional types of thymoma

Diagnosis

Squamous Cell Carcinoma (SCC)

Basaloid Carcinoma

Differential diagnosis

Mucoepidermoid Carcinoma

Lymphoepithelioma-Like Carcinoma

Clear cell carcinoma

Sarcomatoid Carcinoma (Carcinosarcoma)

 “Phenotypic switch”, myoid cells, “triton tumor”, metaplastic thymoma

“orthotopic” counterpart

Adenocarcinomas

NUT (midline) carcinoma

Undifferentiated (Anaplastic) Carcinoma

Rare variants of thymic carcinomas

Cervical Tumors of Thymic or Branchial Pouch Derivation

Ectopic (cervical) thymoma

Ectopic hamartomatous thymoma

Spindle epithelial tumor with thymus-like elements (SETTLE

Microscopically

Differential diagnosis: synovial sarcoma

Carcinoma with thymus-like elements (CASTLE)

 

 

 


Time Table for Tumors of the Mediastinum for Postgraduates
THREE LECTURES 2 HOURS EACH TWO HOURS PRACTICAL SLIDE MICROSCOPIC EXAMINATION FOR STUDENDS OF PATHOLOGY BY THE END OF THE COURSE STUDENTS SHOULD LEARN TUMORS OF THE MEDIASTINUM (A) THYMOMA AND THYMIC CARCINOMACARCINOMA TUMORS OF THE MEDIASTINUM (A) THYMOMA AND THYMIC CARCINOMACARCINOMA CLASSIFIC... Read more