Treatment of 4,6-diamino-3-cyano-2-methylthiopyridine (1) with aqueous KOH or hydrazine hydrate afforded the corresponding nicotinamide 2 and pyrazolo[3,4-b]pyridine 3, respectively. Reaction of compound 1 with bromine, sulfuryl chloride, formaldehyde, or aromatic diazonium salts gave 5- bromopyridine 4, 5-chloropyridine 5, dipyridylmethane 6, and azo dyes 7–10, respectively. Compound 1 reacted with diketones to yield the corresponding butenylamino derivative 11 and amides 12–15, ... إقراء المزيد

Reaction of 4,6-diamino-3-cyano-2-methylthiopyridine (I) with chloroacetyl chloride or acetic acid afforded the corresponding 6-acetamide derivatives IIa and IIb, respectively. Chloroacetamide derivative IIa reacted with various thiols, secondary amines, potassium thiocyanate, compounds containing active methylene group, 1-anilino-2,2-dicyanoethenethiolate, and o-mercatocyanopyridines to give S-alkyl, N-alkyl, thiazole, pyrrole, thiophene, and thienopyridine derivatives, respectively. Antibacterial and anti-inflammatory activities of some new pyridine derivatives were studied. ... إقراء المزيد

4-Anilino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) reacted with formaldehyde and different amines to give Mannich bases 2a–i. Treatment of compound 1 with formaldehyde afforded the corresponding 2-hydroxymethyl derivative 3, which upon its reaction with thionyl chloride yielded the corresponding chloromethyl derivative 4. Treatment of compound 4 with some thiols gave the corresponding sulfides 5a–f. The ring closure reaction of chloromethyl derivative 4 with hydrazine ... إقراء المزيد

Alkylation of 4,6-diamino-3-cyanopyridine-2(1H)-thione (1) with active halo compounds namely; ethyl chloroacetate, chloroacetic acid, 2-chloro-N-phenylacetamide, chloroacetonitrile, or chloroacetamide gave S-alkyl derivatives 2-6, respectively. Thienopyridine derivatives 7-10 were furnished by heating of S-alkyl derivatives 2-6 in hot KOH solution or by reaction of compound 1 with appropriate halo compound directly in hot KOH solution. The reaction of compound 1 with 3-bromopentane-2,4-dione or ... إقراء المزيد

Alkylation of 4-anilino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) with some halo compounds yielded the corresponding sulfides 2a–f. Some sulfides 2e,f were cyclized to give triazolothiadiazines 3 and 4. Triazolothiadiazoles 5 and 6 were prepared through the reaction of compound 1 with carbon disulfide or ethyl orthoformate, respectively. Treatment of compound 1 with ethyl chloroformate or phenyl isothiocyanate yielded triazolo-thiadiazole and triazole 9 and 10, ... إقراء المزيد