BACKGROUND: Acrylamide is reported for its toxicity on the central and the peripheral nervous system and causes paralysis. Bee venom (BV) and bradykinin-potentiating factor (BPF) have been documented for their potential therapeutic effects as anti-neuroinflammation. The study aimed to ameliorate the neurotoxic effects of acrylamide or chips by using BV or its extracted BPF. Mice were divided into 15 subgroups: ... Read more

BACKGROUND: Acrylamide has been reported to induce hepato- and nephrotoxicity. The present investigation aims to alleviate the dangerous effects at the histopathological and physiological levels of acrylamide by bee venom and its extracted bradykinin-potentiating factor (BPF). Seventy-five adult male mice were divided into 15 groups: a control (G1) 15 animals for 30 (G1.1), 45 (G 1.2), and 60 (G 1.3) ... Read more

ALPHA-SYNUCLEIN CONTRIBUTES TO NEURODEGENERATIVE DISEASES THAT ARE CHARACTERIZED WITH THE INCREASE OF ITS EXPRESSION AND COLLECTIVELY KNOWN AS SYNUCLEINOPATHIES SUCH AS PARKINSON’S DISEASE AND DEMENTIA WITH LEWY’S BODIES. A HEALTHY BALANCE OF ALPHA-SYNUCLEIN IS IMPORTANT FOR PREVENTING SYNUCLEINOPATHIES, WHEREAS THE NORMAL PHYSIOLOGICAL ROLE OF ALPHA-SYNUCLEIN IS STILL UNDER INVESTIGATION. THE PRESENT STUDY WAS DESIGNED TO EVALUATE THE INVOLVEMENT OF ALPHA-SYNUCLEIN ... Read more

The present study was conducted to evaluate the effect of caffeine and retinoic acid as the active metabolite form of vitamin A on the liver at pre- and postnatal periods of development. In either the pre- or the postnatal period of study, caffeine was able to perturb carbohydrates, increase calcium and decrease iron those accompanied with down regulated expression of ... Read more

Verapamil is a calcium channel blocker that belongs to the phenylalkylamine group. It has been clinically used for various diseases such as combating hypertension, ischemic heart diseases, supraventricular antiarrhythmic and tycolysis. The study was conducted to investigate the effect of verapamil on selected pro- and apoptotic factors during prenatal retinal differentiation of mice at E14 and E17 of gestation. The ... Read more

أوصف عملية التبطين لكلا من: 1- قنفد البحر 2- فى الطيور Read more