Objective: To investigate the clinical efficacy of neoadjuvant chemotherapy (NAC) with irinotecan (CPT-11) and nedaplatin (NED) followed by radical hysterectomy. Methods: Patients with locally advanced cervical cancer (stage Ib2–IIb) were treated with NAC followed by surgery, primary surgery or primary radiotherapy. NAC was usually performed using transuterine arterial chemotherapy (TUAC) or intravenous CPT-11/NED. Survival rates were analysed in the three ... Read more

Background: Ovarian cancer (OC) is the seventh most common cancer in women and remains a leading cause of gynecologic cancer mortality worldwide and the prevalence continues to rise especially in countries where women consume a ‘Western-style’ diet. Epidemiologic, preclinical and clinical studies suggest a potential role for dietary intake on the incidence and progression of various cancers of the body. ... Read more

_Objective__:_ To investigate the effect of dietary protein quality on ovarian cancer growth and its synergism with an anticancer drug, using murine ovarian cancer models. _Method__:_ We first established four groups of mice, which were fed 20% or 10% animal protein or plant protein, respectively. We injected an ovarian cancer cell line (HM-1) subcutaneously and intraperitoneally into immunocompetent B6C3F1 mice ... Read more

WE EVALUATED WHETHER DIFFERENT DIETARY PROTEIN QUALITIES (ISOCALORIC DIETS INVOLVING ANIMAL (CASEIN) OR PLANT PROTEIN (SOY PROTEIN) COULD INHIBIT THE OVARIAN CANCER GROWTH IN MICE AND IMPROVE THEIR PROGNOSIS AND WHETHER CHEMOTHERAPY HAD DIFFERENT TUMOR REDUCING EFFECTS ON THESE MICE. IN THE MICE OF THE 20% PLANT PROTEIN GROUP, THE OVARIAN CANCER GROWTH AT 5 WEEKS AFTER TUMOR IMPLANTATION WAS ... Read more