Aflatoxin B1 (AFB1) contamination of aquaculture feed poses serious health risks to fish and consumers. In this study, the efficacy of a novel anti-mycotoxin agent specific for aquatic species (AM-AQ) containing bentonite, sepiolite, and orange peel meal (Citrus Sinensis) in alleviating AFB1 toxicity in Nile tilapia (Oreochromis niloticus) was evaluated. Fish were fed a basal diet as a control group ... Read more

Green-synthesized zinc nanoparticles (ZnNP) have attracted considerable attention for use as aqua-feed supplements. The effect of ZnNPs on cellular energy, amino acid metabolism, and gene expression of major histocompatibility-II (_MHC-II_) is poorly understood. Our study explored the effect of dietary ZnNPs supplementation on hepatic function and overall health status. Farmed Nile tilapia cultured in a hapa-culturing system were fed ZnNPs ... Read more

Objectives: Etodolac (ET D), an insoluble anti-inflammatory drug, undergoes first-pass metabolism, which limits its oral bioavailability. The current study presents the trials for improvement of drug solubility on one hand and formulation of different emulgel systems loaded with modified drug on the other hand. Significance: The Prolonged oral administration of ET D results in serious gastrointestinal problems. Therefore, the improvement ... Read more

Pollutants impact fish health, leading to environmental diseases. Anionic surfactant detergents and MPs (MPs) consist serious threat in freshwater environments either lonely or in combination. However, their combined effects are not well studied. Our research therefore focuses on studying the harmful effects of the anionic surfactant sodium lauryl sulfate (SLS) and polyethylene MPs (PMPs) on the biology of freshwater African ... Read more

Cancer remains the most prevalent and challenging disease to treat. It causes millions of deaths around the world every year, requiring advancement in treatment strategies. Nanoparticles (NPs), as drug delivery and targeting devices, are considered promising approaches for cancer treatment and early diagnosis. The current chapter focuses on polymeric NPs (PNPs) applied for the treatment and diagnosis of cancer owing ... Read more

B IO-NANOTECHNOLOGY employing natural products is a promising approach for discovering and developing new drugs for treating various diseases. Chitosan (CH) is a natural product produced from crustacean shells. Recently, both CH and Chitosan nanoparticles (CH-NP) have been used in various pharmaceutical and biomedical applications owing to their unique properties. The main aim of this study was to determine the ... Read more

This study investigates the fabrication of algogenic zinc nanoparticles (ZnNPs), examining their biomimetic properties and potential antibacterial effectiveness against fish pathogens. The rising incidence of antibiotic resistance in aquaculture demands innovative strategies for disease management, highlighting the importance of developing biocompatible and effective antimicrobial agents. In this context, ZnNPs were synthesized using Pediastrum boryanum microalgal extract as the reducing and ... Read more

Maintaining a healthy intestine is essential for growth and host defense mechanisms of farmed fish, particularly those densely stocked. In this context, maintaining a healthy intestinal microbiota for proper digestion, absorption, and integrity of the mucosa is of utmost importance. Nano-form (SeNPs)-enriched _Pediastrum boryanum_ (Turpin) exhibits antimicrobial, antioxidant, and antitumor properties. Therefore, SeNPs are valuable nutrition supplements for farmed aquatic ... Read more

Background Feed supplements, including essential trace elements are believed to play an important role in augmenting fish immune response. In this context, selenium nanoparticles (SeNPs) in fish diets via a green biosynthesis strategy have attracted considerable interest. In this investigation, selenium nanoparticles (SeNPs, 79.26 nm) synthesized from the green microalga Pediastrum boryanum were incorporated into Nile tilapia diets to explore ... Read more

Due to tenoxicam (TX)’s poor aqueous solubility (0.072 mg/ml), it is poorly absorbable in the GIT, and the long-term oral administration of TX may cause severe GIT disturbances. Topical administration of TX can help in bypassing the GIT adverse effects. Therefore, in the present work, we constructed different pluronic/lecithin organogels (PLOs) for topical delivery of TX. PLO was constructed simply ... Read more