Osteoporosis (OP) represents a major public health problem worldwide, and this burden is growing with increasing life expectancy. Postmenopausal OP is a common disease with a spectrum ranging from asymptomatic bone loss to disabling hip fracture. At menopause estrogen deficiency impairs the normal remodeling cycle by increasing osteoclastic resorption activity without a corresponding increase in osteoblastic activity and the amount ...
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