Background: Melasma is a common dyschromia that often motivates the search for dermatological care as it results in cosmetic disfigurement that impairs the patient’s quality of life. Aim: To evaluate the effect of microneedling with addition of topical vitamin c in treatment of melasma. Materials and Methods: This is a prospective study that included 34 adult females with 4 dropouts. ... Read more

Background/Objectives: Cutaneous warts (CW), or verrucae, are benign prolifera- tion of skin that result from infection with human papilloma viruses. Cellular immune reactivity plays a significant role in wart regression. The aim of this study was to elucidate the cellular immune status of patients with CW through measure- ments of their serum levels of interleukin-17 (IL-17) and macrophage migration inhi- ... Read more

Objectives: Varicocele is the most common cause of male infer- tility. It affects spermatogenesis by multiple theories, the most recent is by increasing the levels of reactive oxygen species. Medical treatment in the form of tamoxifen, anti-oxidant (Zinc) and MPFF (Micronised purified flavonoid fractions), may improve sper- matogenesis and semen parameters in patients with varicocele. Our study aims to show ... Read more

Objectives: To study the relationship between Y-chromosome microdeletions with clinical and laboratory findings in infertile men with non-obstructive azoospermia (NOA). Design: Cross-sectional study. Patients: Infertile men with non-obstructive azoospermia (n = 146). Methods: Clinical evaluation and scrotal colour Doppler ultrasonography were evaluated. Standard semen analysis and serum levels of hormones (FSH, LH, total testosterone and prolactin) were performed. Multiplex PCR ... Read more

INTRODUCTION & OBJECTIVES Cutaneous Warts (CW) or verrucae are benign proliferation of skin that result from infection with human papilloma viruses. Cellular immune reactivity plays a significant role in wart regression. To elucidate the cellular immune status of patients with CW through measurements of their serum levels of Interleukin-17 (IL-17) and Macrophage Migration Inhibitory Factor (MIF), hence, identify the possible ... Read more

INTRODUCTION & OBJECTIVES Vitiligo is a common disease with an immunological background. There is no standard treatment regimen for vitiligo. Interleukin 17 (IL-17) may play a role in pathogenesis of vitiligo. Evaluation of Tacrolimus and Narrow band UVB (NB-UVB) in treatment of vitiligo both clinically and by measurement of IL-17 before and after treatment. MATERIALS & METHODS 45 patients with ... Read more

INTRODUCTION: Leptin is a 167 - amino acid polypeptide hormone, identified in 1994 by positional cloning in the mouse and human. This hormone is secreted by the white adipose tissue in proportion to body energy (fat) stored. Leptin functions as a satiety factor in the regulation of body weight. So far, many studies have pointed to a direct role of ... Read more

BACKGROUND: Chronic renal failure or chronic renal disease (CRD) is a progressive oss in renal function over a period of months or years. It is differentiated from acute kidney disease in that the reduction in kidney function must be present for over 3 months Uremic pruritus is the most common cutaneous abnormality in patients with CRF Uraemic pruritus is unrelated ... Read more

Objectives: To study the prevalence and patterns ofY-chromosome microdeletions in infertile men from Upper Egypt and to determine the relationship between Y-chromosome microdeletions with clinical and laboratory findings in these patients. Design: Cross-sectional study. Patients: Infertile men (n = 210) and a control group of fertile men with normal semen analysis (n = 30). Methods: Clinical evaluation, standard semen analysis ... Read more

Background Etiopathogenesis of vitiligo is unclear. Immunological background has a role.Interleukin 17 (IL-17) may play a role in its pathogenesis. There is no standard treatment regimen for vitiligo; however, calcineurin inhibitors may be an effective treatment option. Objective The aim was to evaluate tacrolimus versus narrowband ultraviolet B (NB-UVB) intreatment of vitiligo, both clinically and by measurement of IL-17 before ... Read more