eman_shalabi

Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط

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Genomic Instability Causes HGF Gene Activation in Colon Cancer Cells, Promoting Their Resistance to Necroptosis

2015 | Keywords Genomic Instability, HGF Gene, Colon Cancer, Necroptosis,
Genomic Instability Causes HGF Gene Activation in Colon Cancer Cells, Promoting Their Resistance to Necroptosis
Background & aims: Genomic instability promotes colon carcinogenesis by inducing genetic mutations, but not all genes affected by this process have been identified. We investigated whether genomic instability in human colorectal cancer (CRC) cells produces mutations in the hepatocyte growth factor (HGF) gene. Methods: We genotyped human colon tumor tissues and adjacent nontumor tissues collected from 78 patients University of ... Read more

Utility of Ki-67 labeling index in the differential diagnosis of osteogenic bone tumors

2015 | Keywords osteogenic tumors, labeling index. differential diagnosis, Ki-67,
Utility of Ki-67 labeling index in the differential diagnosis of osteogenic bone tumors
Background and Aims: A group of osteogenic bone tumors can be diagnostically challenging at the histopathological level. These include aggressive osteoblastoma and osteoblastoma-like osteosarcoma. This study aimed at assessing the utility of Ki-67 labeling index in the differentiation between these types of neoplasms. Methods: A total of 39 patients were enrolled in this study, including 9 osteoblastomas (6 conventional and ... Read more

Expression of p53, bcl-2, bax and bcl-xl in ductal carcinoma in situ (DCIS) of the breast.

2014 | Keywords o breast, DCIS, Bcl-xl, Bax, Bcl-2, P53,
Expression of p53, bcl-2, bax and bcl-xl in ductal carcinoma in situ (DCIS) of the breast.
BACKGROUND: DCIS is a malignant proliferation of mammary ductal epithelial cells without invasion beyond the basement membrane. Bcl-2, bax, bcl-xl and p53 are implicated in regulation of apoptosis. This study aimed to clarify the role of these gene products in DCIC. MATERIALS AND METHODS: Immunohistochemical staining of 13 cases of DCIS with bcl-2, bax, bcl-xl and p53 was performed. RESULTS: ... Read more

P0070 E-cadherin and CD10 expression in atypical hyperplastic and malignant endometrial lesions

2014 | Keywords Endometrium, CD10 expression, E-cadherin,
P0070 E-cadherin and CD10 expression in atypical hyperplastic and malignant endometrial lesions
BACKGROUND Loss of E-cadherin is a critical step for development and progression of malignant tumours. CD10, a marker of non-neoplastic and neoplastic endometrial stroma, is associated with aggressiveness of many epithelial malignancies. We sought to evaluate the expression and correlation of E-cadherin and CD10 in endometrial lesions and their possible role in differentiating atypical endometrial hyperplasia from endometrial carcinoma. The ... Read more

Features of gouty arthritis by high frequency ultrasongraphy

2014 | Keywords Gouty arthritis, Ultrasongraphy,
Features of gouty arthritis by high frequency ultrasongraphy
The use of U/S has recently increased in the evaluation of asymptomatic hyperuricemia which may go on for a considerable time before specific manifestations of gout become noticeable. Imaging showing crystal deposition and inflammatory manifestations may lead to the initiation of treatment for gout before the development of irreversible complications (1) . The double contour sign, floating microtophi and full ... Read more

The Value of Desocollin 2 (DSC-2) Expression in Differentiation between Urinary Bladder Transitional and Squamous Cell Carcinoma

2014 | Keywords Bladde, Desocollin 2 (DSC-2),
The Value of Desocollin 2 (DSC-2) Expression in Differentiation between Urinary Bladder Transitional and Squamous Cell Carcinoma
THIS STUDY AIMS to investigate Desmocollin 2 (DSC-2) expression in TCC and SCC, and its role in the differentiation between TCC and SCC. MATERIALS AND METHODS: DSC-2 immunostaining was studied in 90 specimens of bladder carcinomas using avidin-biotin peroxidase method. RESULTS: DSC-2 was strongly expressed in 11/31(35.5%) of invasive TCC. DSC-2 was detected in all TCC with squamous differentiation. DSC-2 ... Read more

Metabolic Factors Associated with Hepatic Steatosis and Fibrosis in Patients with Chronic Hepatitis C

2014 | Keywords Metabolic Factors, Hepatic Steatosis, Fibrosis, Chronic Hepatitis C,
Metabolic Factors Associated with Hepatic Steatosis and Fibrosis in Patients with Chronic Hepatitis C
OBJECTIVE: Hepatic steatosis is a common histological feature in chronic hepatitis C (CHC), but its pathogenic mechanisms are not completely understood. We aimed to evaluate the metabolic factors associated with hepatic steatosis and fibrosis in CHC patients, and the relation between metabolic syndrome (MS) and CHC PATIENTS AND METHODS: This study included 71 patients with chronic HCV infection who underwent ... Read more

TGF-Β1 in patients with chronic HBV infection

2014 | Keywords TGF-Β1, chronic HBV infection,
TGF-Β1 in patients with chronic HBV infection
Background: The transforming growth factor-β1 (TGF-β1) is an important cytokine with anti-inflammatory properties may have a role in pathogenesis of liver fibrosis. Objectives: The main purpose of this study was to compare the serum levels of TGF-β1 in a group of chronic HBV infected (CHB) patients as well as healthy individuals and to determine the correlation between the TGF-β1 and ... Read more

EVALUATION OF PREDICTORS OF SUSTAINED VIROLOGICAL RESPONSE (SVR) TO INTERFERON THERAPY AND HEPATIC PROGENITOR CELLS (HPCS) IN CHRONIC HEPATITIS C VIRUS (HCV) INFECTED PATIENTS

2014 | Keywords SVR, Interferon, liver,
EVALUATION OF PREDICTORS OF SUSTAINED VIROLOGICAL RESPONSE (SVR) TO INTERFERON THERAPY AND HEPATIC PROGENITOR CELLS (HPCS) IN CHRONIC HEPATITIS C VIRUS (HCV) INFECTED PATIENTS
BACKGROUND AND AIMS: Studying the predictors of SVR to pegylated interferon (PEG-INF) alfa-2a and ribavirin (RBV) therapy in chronic HCV infected patients is crucial for selecting those who would benefit most from therapy. Increased HPCs in HCV-infected patients were shown to be correlated with increasing fibrosis and response to treatment. HPCs could be detected in the liver by immunohistochemical expressions ... Read more

Use of PTEN, PCNA, and β-catenin to differentiate between endometrial hyperplasia and endometrial adenocarcinoma

2014 | Keywords PTEN, PCNA, β-Catenin, endometrial hyperplasia, endometrial adenocarcinoma,
Use of PTEN, PCNA, and β-catenin to differentiate between endometrial hyperplasia and endometrial adenocarcinoma
Background The use of PTEN, PCNA, and β-catenin may be of value to differentiate well differentiated endometrioid carcinoma from complex atypical endometrial hyperplasia. Methods Immunohistochemical evaluation of PTEN, PCNA, and β-catenin was performed on 100 specimens including eight proliferative endometrium, 10 secretory endometrium, 10 simple endometrial hyperplasia, 10 complex typical endometrial hyperplasia, 30 complex atypical endometrial hyperplasia, and 32 endometrioid ... Read more