menna.sadik1652

منه الله حسن صديق السيد

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Faculty of medicine

Address: Sohag, Egypt

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A Comparative Assessment of Mechanisms and Effectiveness of Radiosensitization by Titanium Peroxide and Gold Nanoparticles

2020 | Keywords nanoparticlesnon-cytotoxic,
A Comparative Assessment of Mechanisms and Effectiveness of Radiosensitization by Titanium Peroxide and Gold Nanoparticles
The development of potentially safe radiosensitizing agents is essential to enhance the treatment outcomes of radioresistant cancers. The titanium peroxide nanoparticle (TiOxNP) was originally produced using the titanium dioxide nanoparticle, and it showed excellent reactive oxygen species (ROS) generation in response to ionizing radiation. Surface coating the TiOxNPs with polyacrylic acid (PAA) showed low toxicity to the living body and ... Read more

Oral Complications Following Radiation Therapy for Head and Neck Malignancy

2018 | Keywords head and neck cancer; radiati,
Oral Complications Following Radiation Therapy for Head and Neck Malignancy
Each year, head and neck cancer comprises more than 550,000 cases and contributes to 380,000 deaths, worldwide. Radiation Therapy (RT) is used for head and neck cancers as definitive, adjuvant, or palliative treatment. The most important advantage of RT, compared with surgery, is function preservation; however, normal tissue complications occur during (acute complications) or after (subacute and chronic complications) RT ... Read more

Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study

2014 | Keywords 3-bromopyruvate, melanoma, 3-bromopyruvate, melanoma, Warburg effect, lactate dehydrogenase, paracetamol,
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study
3-Bromopyruvate (3BP) is a new, promising anticancer alkylating agent with several notable functions. In addition to inhibiting key glycolysis enzymes including hexokinase II and lactate dehydrogenase (LDH), 3BP also selectively inhibits mitochondrial oxidative phosphorylation, angiogenesis, and energy production in cancer cells. Moreover, 3BP induces hydrogen peroxide generation in cancer cells (oxidative stress effect) and competes with the LDH substrates pyruvate ... Read more

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