CONTEXT: Liver is an interesting organ with high regenerative capacity. OBJECTIVE: giving insight about the cellular, molecular, and genetic mechanisms of liver regeneration, after partial hepatectomy. Studying its clinical applications: 1-Living donor liver transplantation, which is the ethical form of liver transplantation. 2- Cell therapy as an alternative tool for organ donation. The ethics of these application. DATA RESOURCES: evidence ... Read more

Free radicals and oxidative stress can be induced by a variety of factors, such as carbon tetrachloride (CCl4). Ginger (Zingiber officinale Roscoe, Ginger) has antioxidant, antitumoral, and antihepatotoxic activities. Aim of the work The present study was carried out to assess the possible role of ginger on CCl4- induced toxic effects on the pars distalis. Materials and methods Thirty adult ... Read more

INTRODUCTION: Smoking can affect hormone secretion; some of these effects are associated with important clinical implications. These effects are mainly mediated by the action of nicotine. Curcumin is a well known antioxidant agent. AIM OF THE WORK: To study the protective role of curcumin against nicotine induced toxic effects on the adrenal medulla. METHODS: Thirty adult male mice were used ... Read more

INTRODUCTION: Carbon tetrachloride (CCl4) causes hepatic injury, the period of repair of hepatocytes injured by CCl4 and signaling proteins intrinsic to this period were examined. A 30 kDa polypeptide detected by both RT-PCR and Western blott analysis using anti-galectin-3 antibody in livers from mice 48 to 96 h after administration of a single dose of CCl4 was identified as galectin-3 ... Read more

BACKGROUND: Silicosis is a fibronodular lung disease caused by inhalation of dust containing crystalline silica (silicon dioxide). AIM OF THE WORK: To investigate the changes in the lung alveoli after silica dust inhalation on the ultrastructural level in rats. MATERIALS AND METHODS: Thirty adult male albino rats were used and divided into 2 groups (15 animals each); the 1st group ... Read more

Nicotine is a major toxic component of cigarette smoke. Cigarette smoking alters the levels of endogenous steroid hormones. Curcumin is a well known antioxidant agent. Aim of the Work: To study the protective role of curcumin against nicotine induced toxic effects on the adrenal cortex. Materials and Methods: Thirty adult male mice were used and were divided into three groups ... Read more

Tumor necrosis factor-α (TNF-α) plays critical roles in bone resorption at the site of inflammatory joints. The aim of this study is to evaluate the effect of peroxisome proliferator-activated receptor γ (PPAR-γ) agonists, a new class of anti-inflammatory compounds, on TNF-α-mediated osteoclastogenesis in human monocytes. Human monocytes were differentiated into osteoclasts in the presence of TNF-α and macrophage colonystimulating factor. ... Read more

The John Cunningham virus (JCV) asymptomatically infects a large proportion(approximately 90%) of the population worldwide but may be activated inimmunodeficient patients, resulting in progressive multifocalleukoencephalopathy. Recent reports demonstrated its oncogenic role inmalignancies. In this paper, the presence of JCV-targeting T antigen wasinvestigated in tongue carcinoma (TC, n = 39), dysplastic tongue epithelium (DTE,n = 15) and glossitis (n = 15) ... Read more

PURPOSE: NNK [4-(methylnitrosamino)-1-(3-pyridyle)-1-butanone] is anicotine-derived nitrosaminoketone contained in tobacco smoke used as a powerful chemical carcinogen for rodent experimental models of pulmonary carcinogenesis. To clarify its carcinogenetic mechanisms, we examined the expression status of 22,625 mouse genes. METHODS: The affymetrix GeneChip mouse expression 430 A arrays have been used in CD1-induced mouse lung tumor. The affected genes were analyzed by ... Read more

Interleukin-10 (IL-10), an anti-inflammatory cytokine, has been shown to inhibit osteoclast formation and bone resorption in rat and mouse systems. However, the precise intracellular mechanism(s) of this action remains unclear. The aim ofthis study was to clarify the role of IL-10 in the regulation of critical transcription factors involved in osteoclastogenesis. A RAW264.7 macrophage cell line, which constitutively expressed IL-10 ... Read more