عبير شنيف محمد فرغلى

استاذ -

كلية الطب

العنوان: قسم الميكروبيولوجيا الطبية و المناعة


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2017 | الكلمات المفتاحية Chronic Hepatitis C, MicroRNA-122, MicroRNA-155,
Serum MicroRNA-122 and MicroRNA-155: Markers of Disease Progression in Hepatitis C viral infection
Chronic HCV with its longstanding complications of cirrhosis and HCC is a highly prevalent and challenging problem in Egypt. Recently, microRNAs are ranked as potential biomarkers for early diagnosis of HCV related complications. The aim of the present study was to evaluate the role of miRNA-122 and miRNA-155 for prediction of progression of HCV infection and for diagnosis of HCC. ... إقراء المزيد

2017 | الكلمات المفتاحية CA-MRSA, SSTIs, PVL, SCCmec,
Staphylococcal Cassette Chromosome mec Typing of Community- Acquired Methicillin-Resistant Staphylococcus aureus Isolates in Sohag University Hospital, Egypt
Background: community-acquired MRSA is an emerging pathogen increasingly reported worldwide. It is the most commonly reported microorganism to cause skin and soft tissue infections. Objectives: This study aimed to detect CA-MRSA in skin and softtissue infections (SSTIs), their pattern of antibiotic resistance, with molecular characterization of the isolated strains by detection of PVL gene and SCCmec typing. Patients& Methods: A ... إقراء المزيد

2017 | الكلمات المفتاحية Bcl-2, Bax, HCV,
The Role of Bcl-2 and Bax as Markers of Disease Progression in Hepatitis C Virus Infected Patients
Many apoptotic markers have been linked to hepatic cell injury in HCV-related liver diseases, and hence could be used as potential markers for early detection of the disease. The present study aimed to assess the role of apoptotic markers Bcl-2 and Bax in the pathogenesis of chronic HCV-related liver diseases. A total of 85 participants were enrolled into the study; ... إقراء المزيد

2017 | الكلمات المفتاحية PTX3, Gene polymorphism, Pulmonary Tuberculosis,
Pentraxin 3 Genetic Variants and The Risk of Active Pulmonary Tuberculosis
Tuberculosis is a major health problem worldwide. Genetic factors are considered important determinants of the host susceptibility to Mycobacterium tuberculosis. The aim of the current study was to evaluate the association between pentraxin 3 genetic variants and the susceptibility and severity of active pulmonary tuberculosis. The study included 100 patients with newly diagnosed pulmonary TB and 50 healthy controls. PTX3 ... إقراء المزيد

Interleukin-10 and Interferon Gamma Gene Polymorphisms and Hepatitis C Virus–Related Liver Cirrhosis Risk
The aim of the study was to evaluate the association between the gene polymorphisms in interleukin-10 (IL-10) and interferon gamma (IFN-g) genes with susceptibility and severity of hepatitis C virus (HCV) infection among Egyptian patients. Interleukin-10 -592 A/C, -1082 G/A and IFN-g +874 T/A genotypes were determined in 100 chronic HCV patients and 50 healthy controls using restriction fragment length ... إقراء المزيد

2017 | الكلمات المفتاحية neonatal sepsis, lipocalin-2, Cd64, neutrophil CD11b,
Neutrophil CD11b, CD64 and Lipocalin-2: Early Diagnostic Markers of Neonatal Sepsis
Neonatal sepsis remains a global health problem particularly in the developing countries. Its diagnosis remains one of the most difficult issues in clinical medicine. Many immunologic markers including neutrophils CD11b and CD 64 and Lipocalin-2 have been tested as biomarkers of neonatal sepsis. The aim of the present study was to assess the value of these markers for early diagnosis ... إقراء المزيد

2016 | الكلمات المفتاحية HCV, IR, TyG, VAI, Steatosis, ,
Insulin Resistance, Visceral Adiposity Index and TyG Index in Genotype-4 Chronic HCV Patients and Their Relation to Hepatic Histopathology
Introduction: Hepatitis C virus (HCV) genotype 4 is the most prevalent in Egypt. Visceral adiposity index (VAI) and (TyG) index are newly developed indices for assessment of metabolic syndrome (MS) and insulin resistance (IR). We aimed at comparing their levels in HCV-patients with healthy controls and validate their use for prediction of hepatic histopathological changes. Patient and Methods: 78 chronic ... إقراء المزيد

2016 | الكلمات المفتاحية Clostridium difficile, diarrhea, CDAD, multiplex PCR,
Introduction: Clostridium difficile infection (CDI) is emerging as a cause of diarrhea in infants and children in both community and hospital settings. This increasing incidence has been attributed, in part, to the emergence of a hyper virulent strain of C. difficile, increased antibiotic prescriptions, increased awareness of CDI among healthcare providers and emergence of highly sensitive detection methodologies for CDI. ... إقراء المزيد

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