Atherosclerosis had become one of the leading causes of death in the world.1 It has three main manifestations which involve coronary, cerebrovascular and peripheral arteries. Many studies had shown the association between these artery diseases, including the cerebrovascular disease, peripheral artery disease (PAD) and coronary artery disease (CAD).2 The association between the PAD, high risk cardiovascular events and death also ... إقراء المزيد

Background and Objective: Epidemiological and clinical studies have shown that vascular calcification and arterial vascular stiffness are associated with all-cause and cardiovascular (CV) mortality in the general populations and end-stage renal disease (ESRD) patients. The objective of this study was the assessment of arterial stiffness and vascular calcification in ESRD patients in Sohag University Hospital. Patients and Methods: In this ... إقراء المزيد

Abstract Objectives: Several candidate genes are implicated in the pathogenesis of type 2 diabetes mellitus T2DM), one of which is interleukin (IL-10). In this investigation, we aimed to study the association between IL (-592A/C) gene polymorphism with its level in T2DM with and without nephropathy. Methods: IL-10 (-592A/C) gene polymorphism was genotyped using restriction fragment length polymorphism (RFLP-PCR) technique and ... إقراء المزيد

_Apelin, an endogenous peptide exerts its actions through binding to its receptors (APJ receptors) and has been demonstrated in both animal and human studies to have inotropic, diuretic (nitric oxide-dependent), and vasodilator effects, in addition to antagonistic effects on angiotensin II. In this investigation, serum apelin, nitric oxide (NOx), sodium (Na) and potassium (K) were evaluated in patients with essential ... إقراء المزيد

_The liver plays a major role in lipid metabolism, importing free fatty acids and manufacturing, storing, and exporting lipids; derangements in any of these processes can lead to the development of non-alcoholic fatty liver disease (NAFLD). Fatty acid synthase (FAS) is a key enzyme in de novo lipogenesis and circulating FAS is a biomarker of metabolically demanding human diseases. In ... إقراء المزيد

Objective: To analyze immediate and midterm results of percutaneous mitral valvotomy (PMV) in patients ≤ 18 year, a single centre experience of Sohag university hospital. Methods: Between May 2010 and May 2012, 64 procedures of Inoue technique mitral valvotomy were performed on 64 patients. The mean age was 15.8 ± 2.2 years; 75% were females. Results: Success was obtained in ... إقراء المزيد