TUBERCULOSIS IS A MAJOR HEALTH PROBLEM WORLDWIDE. GENETIC FACTORS ARE CONSIDERED IMPORTANT DETERMINANTS OF THE HOST SUSCEPTIBILITY TO MYCOBACTERIUM TUBERCULOSIS. THE AIM OF THE CURRENT STUDY WAS TO EVALUATE THE ASSOCIATION BETWEEN PENTRAXIN 3 GENETIC VARIANTS AND THE SUSCEPTIBILITY AND SEVERITY OF ACTIVE PULMONARY TUBERCULOSIS. THE STUDY INCLUDED 100 PATIENTS WITH NEWLY DIAGNOSED PULMONARY TB AND 50 HEALTHY CONTROLS. PTX3 ... إقراء المزيد

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ine"> 33%) was detected in 54% of the patients, while 21.12% of the patients had stage 3/4 fibrosis. Higher degree of steatosis was significantly associated with higher BMI, serum insulin, HOMA index and TNF-α (P إقراء المزيد

The differential diagnosis of tuberculous and malignant pleural effusion (PE) is extremely difficult and continues to pose clinical challenges. Aim of the study: To evaluate the utility of pleural fluid interferon gamma (IFN-c), tumor necrosis factor-alpha (TNF-a), adenosine deaminase (ADA) levels with T cells subsets in differential diagnosis of malignant (MPE) and tuberculous pleural effusions (TPE). Methods: Forty patients with ... إقراء المزيد

_Clostridium difficile_ infection (CDI) is emerging as a cause of diarrhea in infants and children in both community and hospital settings. This increasing incidence has been attributed, in part, to the emergence of a hypervirulent strain of C. difficile, increased antibiotic prescriptions, increased awareness of CDI among healthcare providers and emergence of highly sensitive detection methodologies for CDI. It is ... إقراء المزيد

Candida species are among the most common fungal pathogens in ICU patients. Candida albicans was the predominant species, but a shift toward non-albicans Candida species has been recently observed. Objectives: To detect the prevalence of different Candida species and determine their antifungal susceptibility profile in ICU patients using phenotypic methods, the Vitek 2 system compared with CHROMagar Candida agar and ... إقراء المزيد

While hepatitis B virus (HBV) and hepatitis C virus (HCV) Infections are important causes of liver disease in end-stage renal failure (ESRF) patients on haemodialysis (HD), prevalence of HBV in those patients has decreased significantly during the past few decades. The immunosuppressive nature of renal disease often leads to chronicity of the HBV infection and an opportunity for nosocomial spread ... إقراء المزيد

There is no gold standard method for detecting latent tuberculosis infection (LTBI) in end stage renal disease (ESRD), the use of tuberculin skin test(TST) remains controversial due to its high rate of false results, new interferon gamma release assays have been developed for diagnosing LTBI as the QuantiFERON-TB Gold test(QFT-G). The aim of this work was to evaluate the value ... إقراء المزيد

Hepatitis C virus (HCV) is one of the endemic viral infections in Egypt and there is no vaccine for HCV, and the only available treatment, a combination of α-interferon and ribavirin, is effective in a minority of patients, various viral and host factors may affect response to treatment. The aim of this work is to examine changes in lymphocyte subpopulations ... إقراء المزيد

ewline"> Type 1 Diabetes Mellitus (T1D) is a T cell-mediated autoimmune disease and is one of the most frequent chronic diseases of children and young adults. It results from immune-mediated destruction of the insulin-producing pancreatic beta cells. AIM OF THE WORK: This study aims to establish the phenotypic characteristics of various lymphocyte populations in type1 Diabetes Mellitus and try to ... إقراء المزيد