Objective: To evaluate the effect of supplementing single-step embryo culture medium with insulin on human embryo development. Design: Comparative study. Setting: Two private centers. Patient(s): The study involved a sibling oocyte split of 5,142 retrieved oocytes from 360 patients. Intervention(s): Sibling oocytes split after intracytoplasmic sperm injection for culture from day 0 through day 5 or 6 in insulin-supplemented or ...
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