Starting with curcumin different pyrane, N-phenyl-1,3-thiazolidin and thiocurcumin derivatives were synthesized. 4-Oxo-3-phenyl1,3-thiazolidin derivative was reacted with different organic reagents examply, benzaldehyde, triethylorthoformate and hydrazine hydrate to form new series of 5-benzylidine-4-oxo-3-phenyl-1,3-thiazolidin, 5-ethoxymethylene-4-oxo-3-phenyl-1,3-thiazolidin and [1,8] naphthyridine derivatives. Some of these derivatives were evaluated as anti- inflammatory agents. All compounds have been characterized by spectral analyses. Read more

[1,3‐Dihydro‐4‐phenyl(1,5)benzodiazepin‐2‐ylidene]malononitrile 1a was treated with formaline and some different primary amines to give the corresponding pyrimido(1,5)benzodiazepines 2a–d. Treatment of compound 1a with halo reagents yielded the corresponding pyrrolobenzodiazepines 3a,b. The reaction of compound 1a with active methylenes, bidentates, S,S‐ and N,S‐acetals afforded the corresponding spiro(1,5)‐benzodiazepines 4a‐c–8a,b, respectively. Read more

Condensation of 4-phenyl-1H-[1,5]benzodiazepin-2(3H)-one (1) with 3-formylchromone (2) afforded a mixture of 3-(chromenylmethylene)[1,5]benzodiazepinone 3 and 14-chromenylbenzodiazepino[ 2,3:6,5]pyrano[2,3-b]benzodiazepine 4. Ring rearrangements of compound 3 with different nucleophilic reagents, such as potassium hydroxide and/or ammonium acetate led to rearrangement into pyranobenzodiazepine 5 and pyridobenzodiazepine 6, respectively. Treatment of compound 3 with hydrazine hydrate, hydroxylamine hydrochloride, malononitrile, cyanothioacetamide, 2-cyano-3,3-disufanylacrylonitrile, and/or 2-cyano-3-phenylamino-3-sufanylacrylonitrile, has been carried ... Read more