Objectives: Tostudyesophagealhighresolutionmanometry(HRM)insystemicsclerosis(SSc)patients and thecorrelationof findings toTheUniversityofCalifornia,LosAngelesSclerodermaClinicalTrials Consortiumgastrointestinaltract2.0(UCLASCTC_GIT2.0). Methods: FortySScpatientswereadministeredtotheUCLASCTCGIT2.0.PatientsunderwentHRMstudy (Solar GIMMS).HRMdatawerecomparedwith15healthyvolunteers. Results: Forty patientswithmeanage46 7 7 yearsanddiseaseduration9.3 7 7 yearsreportedupper (85.7%),lowerGIsymptoms(75%),while5%reportednosymptoms.Mean 7 SD scoresofUCLA SCTC_GIT2.0itemswereasfollows:reflux 1.2 7 0.8, distention1.6 7 1.2,fecalsoiling0.3 7 0.9, diarrhea 0.8 7 1,social1 7 1,emotional1 7 1.1,constipation0.5 7 0.9, andtotalGITscore0.9 7 0.6. Lower esophagealsphincter(LES)pressureanddistalesophagealamplitudeweresignificantly lowerin SSc patientsthancontrols.Mainmanometric findings weredecreasedLESrestingpressure(40%)and aperistalsis(40%).RegressionanalysesshoweddistalesophagealamplitudeandLESrestingpressure negativelycorrelatedwithreflux score(r ¼ −0.64; p ¼ ...
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