SYNTHESIS, STRUCTURAL STABILITY CALCULATION, AND ANTIBACTERIAL EVALUATION OF NOVEL 3,5-DIPHENYLCYCLOHEX-2-EN-1-ONE DERIVATIVES
Starting with 3,5-diphenylcyclohex-2-en-1-one, 3,5-diphenylcyclohex-2-en-1-semicarbazone,1-chloro-3,5-diphenylcyclohex-2-en-2-carbaldehyde,and3,5-diphenylcyclohex2-en-1-hydrazone were synthesized via the reactions with semicarbazide hydrochloride,POCl3= dimethylformamide, and hydrazine hydrate, respectively. These products were used as key intermediates for the preparation of novel series of tetrahydrobenzothiadiazol-1-oxide, indazole, benzo-thiazepines, pentahydroxyhexylidene and N-thiazines. Some of these derivatives exhibit high antibacterial activityagainst Gram-positive bacteria. Read more