amr.hamed1302

Amr Ahmed Hamed

Lecturer - Lecturer at Tropical Medicine and Gastroenterology Department

Faculty of medicine

Address: Sohag, Egypt

2

Like
2 0 0 5 0 2 252 102
64

Newly Added
  • Courses 2
  • Course Supplements 0
  • Courses Tasks 0
  • Publications 5
  • Office hours 0
  • Announcements 2
  • File uploaded 2
  • Downloaded Times 2

Publications Which contain the keyword: Naproxen

3. Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies

2019-12-10 00:08:59 Keywords Aryl carboximidamides 1, 2, 4-, Aryl carboximidamides, 1, 2, 4-oxadiazoles, COX-1, COX-2, 15- LOX, Naproxen, anti-inflammatory,
3. Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies
A series of novel naproxen analogues containing 3-aryl-1,2,4-oxadiazoles moiety (4b-g) and their reaction intermediates aryl carboximidamides moiety (3b-g) was synthesized and evaluated in vitro as dual COXs/15-LOX inhibitors. Compounds 3b-g exhibited superior inhibitory activity than celecoxib as COX-2 inhibitors. Compounds 3b-d and 3g were the most potent COX-2 inhibitors with IC50 range of 6.4 – 8.13 nM and higher selectivity ... Read more

Synthesis of New Potential Chemotherapeutic Agents Incorporating Naproxen Sub-Structure

2018-10-29 12:52:55 Keywords Potential Chemotherapeutic Age, Naproxen,
Synthesis of New Potential Chemotherapeutic Agents Incorporating Naproxen Sub-Structure
Synthesis of New Potential Chemotherapeutic Agents Incorporating Naproxen Sub-Structure Read more

  • «
  • 1
  • »