Mahmoudalmenshawy

Mahmoud Mohamed Ahmed Elsayed

Professor - Former Dean of Faculty of Pharmacy- Sohag University

Faculty of Pharmacy

Address: Faculty of Pharmacy, Pharmaceutics and Clinical Pharmacy Department,Sohag University, Sohag, Egypt

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Publications Which contain the keyword: Torsemide


2020-03-25 03:19:58 Keywords Torsemide,
Enhancement of Solubility and Dissolution Rate of Torsemide as Poorly Soluble Loop Diuretic by Inclusion Complexation with both β -Cyclodextrin and Hydroxypropyl-β -Cyclodextrin
Torsemide (1-(1-Methylethyl)-3-[[4-[(3 methyl phenyl) amino] pyridin-3-yl] sulphonyl] urea) is an insoluble loop diuretic drug. Torsemide (TSM) is used for the treatment of oedema associated with heart failure, including pulmonary oedema, and with renal and hepatic disorders. It is also used in the treatment of hypertension, either alone or in combination with other antihypertensive drugs. Complexation of the drug with beta ... Read more

2018-11-26 16:54:53 Keywords Fast Dissolving tab, Torsemide,
Torsemide Fast Dissolving Tablets: Development, Optimization Using Box-Bhenken Design and Response Surface Methodology, In Vitro Characterization, and Pharmacokinetic Assessment.
ABSTRACT The present study planed to develop new fast dissolving tablets (FDTs) of torsemide. Solid dispersions (SDs) of torsemide and sorbitol (3:1) or polyvinylpyrrolidone (PVP) k25 were prepared. The prepared SDs were evaluated for in-vitro dissolution. Fourier transform infrared spectroscopy and differential scanning calorimetry for SDs revealed no drug/excipient interactions and transformation of torsemide to the amorphous form. Torsemide/sorbitol SD ... Read more

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