Synthesis of novel coumarin derivatives based on 6-aminocoumarin, kinetics inspection of base hydrolysis, and spectrophotometric tracer of intermediate progress
The kinetics of the base hydrolysis of 6-aminocoumarin and some of its derivatives was studied spectrophotometrically in aqueous medium at 298 K under pseudo-firstorder conditions ([OH-][[[Compound]). The suggested general rate equation can be given as: rate = {k1 ? k2 [OH-]} [complex]. The reasonable mechanism suggested that the investigated reaction proceeded via the formation of an intermediate and the ring ... Read more