Few therapies are known to enhance diastolic function. Systemic administration of natriuretlc peptldes (NP) improves diastolic function. However, this may be due to effects on load, rather than a direct myocardlal action. We generated mice with acar-disc-specific (a-MHC promoter) gain-of-function mutation (GoF, HCAT E974A) in the natriuretic peptide A receptor (NPRA) resulting in myocyte-specific constitutive NPRA activation. We hypothesized that ...
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