Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط



Publications Which contain the keyword: Bcl-2

2018-10-22 21:36:49 Keywords Carcinoma, adenoma, Colorectal, ApopTag, Ki-67., P53, Bax, Bcl-2,
Immunohistochemical Study, In Situ Hybridization and Computerized Image Analysis of Colorectal Epithelial Progression from Adenoma to Carcinoma
SUMMARY: Adenoma-carcinoma sequence was postulated for most colorectal carcinomas. Deregulation of apoptosis and cellular proliferation is involved in the pathogenesis of neoplasia. The apoptotic genes that have been characterized in colon cancer are bcl-2, bax, and p53. Studying the expression of these genes and of the proliferating cell marker (Ki-67) in adenoma carcinoma sequence well be of great value in ... Read more

2018-10-22 22:17:49 Keywords Carcinoma, Colorectal, ApopTag, Ki-67, P53, Bax, Bcl-2,
Apoptosis and Colorectal Carcinoma; a Multiparameter Immunohistochemical, and Computerized Image Analysis Study
ABSTRACT: The last few years showed an increase in the incidence of the colorectal cancer in Egypt. Between 20% and 50% of patients with this cancer are susceptible to death within five years of diagnosis. Tumor growth results from a disturbance in the balance between the rates of cell proliferation and cell death (apoptosis). We studied the expressions of proteins ... Read more

2018-10-22 23:23:31 Keywords Psoriasis Vulgaris, IL-6, Bcl-2, Serum Soluble Fas,
Serum Soluble Fas, Bcl-2 Proteins and IL-6 Levels in Patients with Psoriasis Vulgaris and their correlations to disease activity.
INTRODUCTIONF: as (Apo-I /CD95) is a widely expressed membrane-anchored protein that induces apoptosis. Keratinocytes constitutively express the Fas antigen and Fas- mediated apoptosis may characterize several pathological conditions affecting human skin. Soluble Fas (sFas) has been demonstrated in serum by alternative mRNA splicing of Fas receptor. It can antagonize cell surface Fas function by downregulating Fas- mediated apoptosis and its ... Read more

2018-10-23 20:22:05 Keywords Colorectal cancer, adenoma, Carcinoma, , Bcl-2, Bax , P53, Ki-67, , ApopTag, , β-Catenin,
Markers defining colorectal adenoma-carcinoma progression: a computerized image analysis protocol
ABSTRACT: The vast majority of colorectal carcinoma are widely believed to arise from polypoid adenomas. The apoptotic related genes that have been most consistently characterized in colonic cancer are bcl-2, bax, and p53. Studying the expression of these genes in adenoma carcinoma sequence will be of great value in producing the clinical behavior of benign tumors. Loss of contact inhibition ... Read more

2018-10-16 15:17:40 Keywords Bcl-2, Bax, P53, STAT3, β-Catenin, COLON, adenoma, Carcinoma,
Comparative study of Bcl-2, Bax, p53, STAT3 and β-catenin and their relationship to colonic epithelial progression from adenomas to carcinomas: a multiparameter immunohistochemical computerized image analysis study
ABSTRACT: Adenoma-carcinoma sequence was postulated for most colorectal carcinomas. Deregulation of apoptosis & cell proliferation is involved in the pathogenesis of neoplasia. The apoptosis genes characterized in colon cancer are bcl-2, bax & p53. b-catenin plays a role in both cell adhesion & intracellular signaling. Translocation of b-catenin from the cell membrane to the cytoplasm or nucleus is an early ... Read more

Immunohistochemical  study  of  BcL-2protein  and  Estrogen-receptor-alpha  expression  in  benign  prostatic  hyperplasia  and prostatic  carcinoma
Abstract:The human prostate, a male sexual accessory tissue involved in seminal fluid production, has a remarkably high incidence of hyperplastic and neoplastic disease. the present study was carried out on one hundered and twenty(120) specimens divided into two groups; group 1:Included forty cases of benign prostatic hyperplasia(BPH) and group 2:Included sixty cases ofprostatic adenocarcinoma (PC) (22 were low grade;GS: 2-6 ... Read more

2018-10-02 13:04:20 Keywords Bcl-2, Bax, HCV,
The Role of Bcl-2 and Bax as Markers of Disease Progression in Hepatitis C Virus Infected Patients
Many apoptotic markers have been linked to hepatic cell injury in HCV-related liver diseases, and hence could be used as potential markers for early detection of the disease. The present study aimed to assess the role of apoptotic markers Bcl-2 and Bax in the pathogenesis of chronic HCV-related liver diseases. A total of 85 participants were enrolled into the study; ... Read more

2018-09-12 15:34:13 Keywords o breast, DCIS, Bcl-xl, Bax, Bcl-2, P53,
Expression of p53, bcl-2, bax and bcl-xl in ductal carcinoma in situ (DCIS) of the breast.
BACKGROUND: DCIS is a malignant proliferation of mammary ductal epithelial cells without invasion beyond the basement membrane. Bcl-2, bax, bcl-xl and p53 are implicated in regulation of apoptosis. This study aimed to clarify the role of these gene products in DCIC. MATERIALS AND METHODS: Immunohistochemical staining of 13 cases of DCIS with bcl-2, bax, bcl-xl and p53 was performed. RESULTS: ... Read more

2018-09-06 09:17:46 Keywords Breast Carcinoma, Bax, Bcl-2,
Evaluation of Immunohistochemical Anti-apoptotic Bcl-2 and Pro-apoptotic Bax Gene Products in Breast Carcinoma
One of the greatest challenges in breast cancer management is to accurately predict the outcome for each patient. To do this at present, we rely heavily on traditional pathological variables, such as tumor size, tumor grade and lymph node status. However, despite the broad applicability of clinico-pathological indices, they are still unable, to separate the 30% node-negative patients who will ... Read more

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