ghada_galal

Ghada Galal

Professor - Head of Tropical Medicine and Gastroenterology Department

Faculty of medicine

Address: Sohag, Egypt

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Publications Which contain the keyword: P53

Immunohistochemical P53 Expression in Breast Carcinoma with Correlation to Clinico-Pathological Parameters

2018-09-06 09:22:28 Keywords P53, Breast Carcinoma, Clinico-pathological Parameters,
Immunohistochemical P53 Expression in Breast Carcinoma with Correlation to Clinico-Pathological Parameters
Breast cancer has emerged as a grave danger in the last 50 years. It represented 35.1% of total cancer in women in Egypt National Cancer Institute (NCI) series. Changes in cell loss factor could have a major impact on tumor growth or regression. A large percentage of cell loss from tumors was due to apoptosis. P53 is a tumor suppressor ... Read more

Immunohistochemical Cyclooxygenase-2 (COX-2) and P53 expression in Breast Carcinoma with Correlation to Clinico-pathological Parameters

2018-09-06 09:26:34 Keywords Clinico-pathological Parameters, Breast Carcinoma, P53, COX-2,
Immunohistochemical Cyclooxygenase-2 (COX-2) and P53 expression in Breast Carcinoma with Correlation to Clinico-pathological Parameters
BACKGROUND/AIMS: Breast cancer is the most common cancer in Egyptian women. This study aims to: 1. Evaluate COX-2 and p53 expressions in the successive steps of breast carcinogenesis. 2. Determine the correlation between COX-2 and p53 with the clinico-pathological parameters in ductal breast carcinoma. PATIENTS AND METHODS: This study included 74 specimens of breast lesions. Data about patient’s age, tumor ... Read more

Evaluation of the Proliferation Index and p53 Protein Expression in Preinvasive and Invasive Breast Carcinoma

2018-09-07 10:14:51 Keywords P53, Expression, Breast Carcinoma,
Evaluation of the Proliferation Index and p53 Protein Expression in Preinvasive and Invasive Breast Carcinoma
BACKGROUND: Breast cancer is the most frequently diagnosed cancer and the most common cause of cancer deaths in women worldwide. Ki67 is a biomarker that reflects cell proliferation. Despite a clear understanding of the structure and properties of this protein, its functional role remains elusive. Gene expression alteration confers the potential for invasive growth in the preinvasive stages of breast ... Read more

Expression of apoptosis-regulating proteins p53, and bax in primary resected esophageal squamous cell carcinoma

2018-09-08 11:33:46 Keywords Apoptosis, esophagealus, Esophagus, P53, Bax, squamous cell carcinoma,
Expression of apoptosis-regulating proteins p53, and bax in primary resected esophageal squamous cell carcinoma
ABSTRACT Currently, clinico-pathological staging and classification of residual tumor are the most important prognostic factors for clinical outcome in esophageal cancer. Nevertheless, patients with similar stages of the disease show a marked discrepancy in survival. Several new molecular prognostic factors are being evaluated in the hope that they may contribute to better assessment of the survival probability and, consequently, the ... Read more