Mahmoudalmenshawy

Mahmoud Mohamed Ahmed Elsayed

Professor - Former Dean of Faculty of Pharmacy- Sohag University

Faculty of Pharmacy

Address: Faculty of Pharmacy, Pharmaceutics and Clinical Pharmacy Department,Sohag University, Sohag, Egypt

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Publications Which contain the keyword: sorafenib


Design And Characterisation Of Novel Sorafenib-Loaded Carbon Nanotubes With Distinct Tumour-Suppressive Activity InHepatocellular Carcinoma
PURPOSE Over the past 30 years, no consistent survival benefits have been recorded for anticancer agents of advanced hepatocellular carcinoma (HCC), except for the multikinase inhibitor sorafenib (Nexavar®), which clinically achieves only ~3 months overall survival benefit. This modest benefit is attributed to limited aqueous solubility, slow dissolution rate and, consequently, limited absorption from the gastrointestinal tract. Thus, novel formulation ... Read more

2019-12-29 22:00:57 Keywords sorafenib, carbon nanotubes,
Accelerated Stability Testing of Microcapsulated Sorafenib-loaded Carbon nanotubes Prepared by emulsification/internal gelation Method
This work aims to evaluate the effect of environmental factors, including temperature, humidity, and light, on the quality of a drug substance or a formulated product which is utilized for prediction of its shelf life, to determine proper storage conditions and to suggest labeling instructions. Moreover, the data generated during the stability testing is an important requirement for regulatory approval ... Read more

2019-12-29 22:07:31 Keywords Microspheres, sorafenib,
EFFECT OF DIFFERENT FORMULATION VARIABLES ON RELEASE CHARACTERISTICS OF GASTRO-FLOATING MICROSPHERES OF ETHYL CELLULOSE/CARBOPOL 934P ENCAPSULATING SORAFENIB
Objective: The aim of this study is to prepare floating hollow microspheres encapsulating Sorafenib (SFN) to enhance its oral bioavailability. Methods: Gastro-floating hollow adhesive microspheres containing SFN were produced by using an emulsion solvent evaporation technique with ether and ethanol as solvents. Ethyl cellulose and carbopol 934P were used as the encapsulating carriers. The effects of formulation parameters like, solvent ... Read more

2019-12-29 22:25:32 Keywords sorafenib, Nanotechnology,
Design And Characterisation Of Novel Sorafenib-Loaded Carbon Nanotubes With Distinct Tumour-Suppressive Activity In Hepatocellular Carcinoma
Purpose: Over the past 30 years, no consistent survival benefits have been recorded for anticancer agents of advanced hepatocellular carcinoma (HCC), except for the multikinase inhibitor sorafenib (Nexavar®), which clinically achieves only ~3 months overall survival benefit. This modest benefit is attributed to limited aqueous solubility, slow dissolution rate and, consequently, limited absorption from the gastrointestinal tract. Thus, novel formulation ... Read more

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