EFFECT OF DIFFERENT FORMULATION VARIABLES ON RELEASE CHARACTERISTICS OF GASTRO-FLOATING MICROSPHERES OF ETHYL CELLULOSE/CARBOPOL 934P ENCAPSULATING SORAFENIB
Objective: The aim of this study is to prepare floating hollow microspheres encapsulating Sorafenib (SFN) to enhance its oral bioavailability. Methods: Gastro-floating hollow adhesive microspheres containing SFN were produced by using an emulsion solvent evaporation technique with ether and ethanol as solvents. Ethyl cellulose and carbopol 934P were used as the encapsulating carriers. The effects of formulation parameters like, solvent ... Read more