PURPOSE: In animals and patients with left ventricular dysfunction, shortterm A1 adenosine receptor blockade causes diuresis/natriuresis without altering potassium excretion and, in contrast to loop diuretics, improves renal function. Blockade of the A2b adenosine receptor has an antidiabetic effect. The purpose of this study was to examine the long-term efficacy and safety of BG9928, a novel, orally active, and highly ...
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