Background/Aims: Differential diagnosis between aggressive osteoblastoma and low grade osteosarcoma may be very diffi cult or even impossible on a small biopsy. This study was designed to assess the usefulness of immunoexpression of COX-2 and osteocalcin in the differential diagnosis of the two tumour types. Methods: Immunostaining of COX 2 and osteocalcin were studied in 9 osteoblastomas and 30 osteosarcomas. ... Read more

BACKGROUND: Osteoblastoma and osteosarcoma are primary bone forming tumors that show different clinical behavior and radiological/pathological features. In the majority of cases the two entities may easily be separated. Occasionally, however osteoblastoma may resemble osteosarcoma histologically, and the differential diagnosis between aggressive osteoblastoma and low grade osteosarcoma may be very difficult or even impossible on a small biopsy sample. AIMS: ... Read more

_BACKGROUND/AIMS:_ Osteoblastoma and osteosarcoma are primary bone forming tumors that show different radiological/pathological features and clinical behavior. This study aims to specify the expression profile of Ki-67 and osteocalcin in osteoblastomas and osteosarcomas._METHODS:_Ki-67 and osteocalcin immunoexpression were studied in 9 osteoblastomas and 30 osteosarcomas; including 27 osteoblastic osteosarcomas._RESULTS:_There was gradual significant increase (pCONCLUSION:_ Ki-67 increased ongoing from osteoblastomas through low ... Read more