Mahmood Ahmed Hamed Ahmed

Lecturer - Lecturer

Faculty of medicine

Address: Otorhinolaryngology Department, Sohag University Hospitals, Sohag, 82524, Egypt



Publications Which contain the keyword: Immunohistochemistry

2020-03-03 08:23:59 Keywords Immunohistochemistry, metastin, Endometriosis, KISS1, Kisspeptin,
Immunoreactivity of Kisspeptin and Kisspeptin Receptor in Eutopic and Ectopic Endometrial Tissue of Women With and Without Endometriosis
Endometriosis is characterized by the presence of ectopic endometrial tissues. Mechanisms of tissue dissemination in endometriosis may be similar to those involved in tumor metastasis. We hypothesize that dysregulation of kisspeptin (KISS1), a metastasis suppressor in endometrial carcinoma, may contribute to the pathogenesis of endometriosis. In this study, we characterized the immunoreactivity of kisspeptin and its receptor, KISS1R, in eutopic ... Read more

Immunohistochemical Study To Evaluate the Expression Of DSC-2, COX-2, and CK-14in Urothelial Carcinoma and Squamous Cell Carcinoma of the Urinary Bladder
The purpose of this study was to identify sites of squamous differentaion in urothelial carcinoma of the urinary bladder, to differntaite between urothelial carcinoma and squmaous cell carcinoma of the urinary baldder specially those poorly differntiated forms using DSC-2, COX-2 and CK-14 and to corelate these markers with avilalable clinical and histological parameters in urinary bladder Read more

2018-10-22 19:59:20 Keywords cholesteatoma, Acquired, cytokeratin, Immunohistochemistry,
Cytokeratin expression pattern in acquired cholesteatoma versus meatal skin; an immunochemical study.
Cholesteatoma is a proliferative disease of the middle ear with bone resorption activity. Its pathogenesis remains controversial and has yet to be clarified. Cytokeratins represent a well-known epithelial proliferative and differentiation markers. In the current study, we investigated expression of a large set of cytokeratins in cholesteatoma matrix versus deep meatal skin tissues from the same patients. Methodology: An immunohistochemical ... Read more

2018-10-22 20:09:15 Keywords cholesteatoma, staging, Immunohistochemistry, cancer,
SOM CLEFT Scoring/Staging System for Tympanomastoid Cholesteatoma
_OBJECTIVES_: To adopt a newly designed scoring/staging system for of tympanomastoid cholesteatoma similar to cancer staging protocols. _METHODS_: Our system relied on clinical, CT findings, and confirmed with intraoperative findings. All bony items that could be affected by cholesteatoma were scored, including: scutum (S), ossicles (O), mastoid (M), posterior canal wall (C), lateral sinus plate (L), inner ear (E), facial ... Read more

Dietary protein restriction inhibits the development of ovarian cancer
_Objective__:_ To investigate the effect of dietary protein quality on ovarian cancer growth and its synergism with an anticancer drug, using murine ovarian cancer models. _Method__:_ We first established four groups of mice, which were fed 20% or 10% animal protein or plant protein, respectively. We injected an ovarian cancer cell line (HM-1) subcutaneously and intraperitoneally into immunocompetent B6C3F1 mice ... Read more

Localization and Regulation of Aquaporins in the Murine Larynx
Conclusion: Expression of AQPs in the vocal folds and the parasympathetic regulation of AQPs in the laryngeal glands may be important for controlling laryngeal secretion and vocal fold hydration. These findings are thought to be an initial step towards understanding potential mechanisms of water flow through the vocal fold surface. Objectives: Lubrication of the vocal folds is important for phonation ... Read more

Immunohistological Study Of KI-67 (MIB-1) Antigen Expression In Superficial Bladder Carcinoma
ABSTRACT Superficial bladder carcinoma particularly grade 2 is a heterogeneous widespread group comprising both non- invasive (pTa) and invasive (pTI) tumors. Therefore, the study of its proliferative activity by immunohistochemical detection of Ki-67 antigen is necessary to highlight the biologic behavior of such lesion. This study was performed on sixty (60) retrospective cases of primary superficial bladder carcinomas (pTa and ... Read more

2018-09-29 08:27:06 Keywords Osteocalcin, Osteosarcoma, Osteoblastoma, Immunohistochemistry,
Role of immunohistochemical cyclo-oxygenase-2 (COX-2) and osteocalcin in differentiating between osteoblastomas and osteosarcomas
Background/Aims: Differential diagnosis between aggressive osteoblastoma and low grade osteosarcoma may be very diffi cult or even impossible on a small biopsy. This study was designed to assess the usefulness of immunoexpression of COX-2 and osteocalcin in the differential diagnosis of the two tumour types. Methods: Immunostaining of COX 2 and osteocalcin were studied in 9 osteoblastomas and 30 osteosarcomas. ... Read more

2018-09-24 00:59:16 Keywords Western blot, IL‐17, Immunohistochemistry, ELISA, acne, 25(OH)D3,
Lesional and circulating levels of interleukin‐17 and 25‐ hydroxycholecalciferol  in active acne vulgaris: Correlation to disease  severity
OBJECTIVES: The immunological aspects of inflammatory acne are still incompletely understood, so this study aimed to investigate the possible role of IL‐17 and 25 hydroxycholecalciferol (25(OH)D3) in the disease pathogenesis and progression. MATERIALS AND METHODS: Across‐sectional study has been conducted on 135 patients with active acne vulgaris of various severities and 150 matched controls. ELISA assays of serum and tissue ... Read more

2018-09-13 04:12:49 Keywords Immunohistochemistry, Kisspeptin, Endometriosis,
Differential expression of Kisspeptin in patients with and without endometriosis
OBJECTIVE Kisspeptin is a neuropeptide that belongs to the Rfamide family. It is known for its crucial role in regulating the onset of puberty. In addition it also regulates sex hormone mediated secretion of gonadotrophins. Recently, expression of Kisspeptin in endometrium was reported. Kisspeptin has also been shown to have antimetastatic properties in different types of cancer. Endometriosis shares many ... Read more