ghada_galal

Ghada Galal

Professor - Head of Tropical Medicine and Gastroenterology Department

Faculty of medicine

Address: Sohag, Egypt

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Publications Which contain the keyword: Bcl-xl

Expression of p53, bcl-2, bax and bcl-xl in ductal carcinoma in situ (DCIS) of the breast.

2018-09-12 15:34:13 Keywords o breast, DCIS, Bcl-xl, Bax, Bcl-2, P53,
Expression of p53, bcl-2, bax and bcl-xl in ductal carcinoma in situ (DCIS) of the breast.
BACKGROUND: DCIS is a malignant proliferation of mammary ductal epithelial cells without invasion beyond the basement membrane. Bcl-2, bax, bcl-xl and p53 are implicated in regulation of apoptosis. This study aimed to clarify the role of these gene products in DCIC. MATERIALS AND METHODS: Immunohistochemical staining of 13 cases of DCIS with bcl-2, bax, bcl-xl and p53 was performed. RESULTS: ... Read more

Studying of Apoptosis in Breast Carcinoma; Immunohistochemical Evaluation of Pro- and Anti-apoptotic Gene Products Bax and Bcl-xl

2018-09-06 09:20:17 Keywords Apoptosis, Breast Carcinoma, Bax, Bcl-xl,
Studying of Apoptosis in Breast Carcinoma; Immunohistochemical Evaluation of Pro- and Anti-apoptotic Gene Products Bax and Bcl-xl
Cancer cells acquire their hallmarks of malignancy through the accumulation of gene activation and inactivation over long periods of time. Gene expression studies offer the greatest promise for refining prognostication in breast cancer. For breast cancer, this multistep process may manifest itself as a sequence of pathologically defined stages. Dys-regulation of apoptosis overrides many of the normal checkpoint pathways and ... Read more

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