Lobna Abdel-Mohsen Ebaid Nassr

Professor - Head Of Chemistry Department- Director of Quality Management Unit - Faculty of Science - Sohag University

Faculty of science

Address: Chemistry Department - Faculty of Science - Sohag University



Publications Which contain the keyword: antibacterial

Synthesis, in vitro Antibacterial and in vivo Anti-inflammatory Activity of Some New pyridines
Reaction of 4,6-diamino-3-cyano-2-methylthiopyridine (I) with chloroacetyl chloride or acetic acid afforded the corresponding 6-acetamide derivatives IIa and IIb, respectively. Chloroacetamide derivative IIa reacted with various thiols, secondary amines, potassium thiocyanate, compounds containing active methylene group,1-anilino-2,2-dicyanoethenethiolate, and o-mercatocyanopyridines to give S-alkyl, N-alkyl, thiazole, pyrrole, thiophene, and thienopyridine derivatives, respectively. Antibacterial and anti-inflammatory activities of some new pyridine derivatives were studied. Read more

2018-09-10 12:57:58 Keywords Triazolotriazoles;, Oxadiazolotriazoles;, antibacterial,
“Synthesis and Antibacterial Activity of Some New 4-anilino-5-phenyl-4H-1,2,4-triazole-3-thiol derivatives
4-Anilino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) reacted with formaldehyde and different amines to give Mannich bases 2a–i. Treatment of compound 1 with formaldehyde afforded the corresponding 2-hydroxymethyl derivative 3, which upon its reaction with thionyl chloride yielded the corresponding chloromethyl derivative 4. Treatment of compound 4 with some thiols gave the corresponding sulfides 5a–f. The ring closure reaction of chloromethyl derivative 4 with hydrazine ... Read more

2018-09-10 13:00:55 Keywords Antifungal, antibacterial, S-alkylpyridines, thienopyridines,
Synthesis and Biological Evaluation of Some Novel Thienopyridines
Alkylation of 4,6-diamino-3-cyanopyridine-2(1H)-thione (1) with active halo compounds namely; ethyl chloroacetate, chloroacetic acid, 2-chloro-N-phenylacetamide, chloroacetonitrile, or chloroacetamide gave S-alkyl derivatives 2-6, respectively. Thienopyridine derivatives 7-10 were furnished by heating of S-alkyl derivatives 2-6 in hot KOH solution or by reaction of compound 1 with appropriate halo compound directly in hot KOH solution. The reaction of compound 1 with 3-bromopentane-2,4-dione or ... Read more