eman_shalabi

Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط

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Publications Which contain the keyword: anti-inflammatory

Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies

2019-04-26 22:38:01 Keywords Aryl carboximidamides1, 2, 4-o, Aryl carboximidamides, 1, 2, 4-oxadiazoles, COX-1, COX-2, 15- LOX, Naproxe, anti-inflammatory,
Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies
A series of novel naproxen analogues containing 3-aryl-1,2,4-oxadiazoles moiety (4B-G) and their reaction intermediates aryl carboximidamides moiety (3B-G) was synthesized and evaluated _in vitro_ as dual COXs/15-LOX inhibitors. Compounds 3B-G exhibited superior inhibitory activity than celecoxib as COX-2 inhibitors. Compounds 3B-D and 3G were the most potent COX-2 inhibitors with IC50 range of 6.4 – 8.13 nM and higher selectivity ... Read more

3. Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies

2019-12-10 00:08:59 Keywords Aryl carboximidamides 1, 2, 4-, Aryl carboximidamides, 1, 2, 4-oxadiazoles, COX-1, COX-2, 15- LOX, Naproxen, anti-inflammatory,
3. Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies
A series of novel naproxen analogues containing 3-aryl-1,2,4-oxadiazoles moiety (4b-g) and their reaction intermediates aryl carboximidamides moiety (3b-g) was synthesized and evaluated in vitro as dual COXs/15-LOX inhibitors. Compounds 3b-g exhibited superior inhibitory activity than celecoxib as COX-2 inhibitors. Compounds 3b-d and 3g were the most potent COX-2 inhibitors with IC50 range of 6.4 – 8.13 nM and higher selectivity ... Read more

Efficient Protocol for the One-Pot Multicomponent Synthesis of Novel 2-Tosyloxyphenylpyrans and Schiff bases with Anti-inflammatory and Antioxidant Activities

2018-09-12 21:29:43 Keywords anti-inflammatory, one-pot Multicomponent synthes, one-pot Multicomponent synthes,
Efficient Protocol for the One-Pot Multicomponent Synthesis of Novel 2-Tosyloxyphenylpyrans and Schiff bases with Anti-inflammatory and Antioxidant Activities
1442One-PotMulticomponentSynthesisofNovel2-Tosyloxyphenylpyrans underGreenandConventionalConditionwithAnti-inflammatoryActivity Vol54 AhmedKhodairy, a AliM.Ali, a * MoustafaO.Aboelez, b andM.T.El-Wassimy a a DepartmentofOrganicChemistry,FacultyofScience,SohagUniversity,Sohag82524,Egypt b DepartmentofPharmaceuticalMedicinalChemistry,FacultyofPharmacy,SohagUniversity,Egypt *E-mail:elssan@yahoo.com AdditionalSupportingInformationmaybefoundintheonlineversionofthisarticle. ReceivedApril16,2016 DOI10.1002/jhet.2730 Publishedonline19July2016inWileyOnlineLibrary(wileyonlinelibrary.com). Amild,efficient,andenvironmentallygreenprotocolforthesynthesisof2-tosyloxyphenylpyran derivatives3-11viareactionof2-tosyloxybenzaldehyde(1)withmalononitrileandsomeketonicreagents inone-pot,threecomponentreactionwithinfewminutesunderstirringinmethanolinpresenceofammonium hydroxidesolutionorultrasonicirradiation.Ontheotherhand,thesameproducts3-11wereobtainedby traditionalmethod,ontreatmentof2-tosyloxybenzilidinemalononitrile(2)withthesameketonicreagents inrefluxingethanolinpresenceofTEA.2-Tosyloxyphenylpyranopyrazoles12and13wereobtainedvia treatmentofcompound1withmalononitrile,hydrazinehydrateorphenylhydrazineandethylacetoacetate, inone-pot,multicomponentreaction(MCRs).Thestructuresofthenewcompoundswereelucidatedbyele- mentalandspectralanalyses.Thenewlysynthesizedcompoundsshowedpromisinganti-inflammatoryactivity Read more

Synthesis, in vitro Antibacterial and in vivo Anti-inflammatory Activity of Some New pyridines

2018-09-10 12:54:57 Keywords Pyridines, thiophenes, thienopyridines, antibacterial, anti-inflammatory,
Synthesis, in vitro Antibacterial and in vivo Anti-inflammatory Activity of Some New pyridines
Reaction of 4,6-diamino-3-cyano-2-methylthiopyridine (I) with chloroacetyl chloride or acetic acid afforded the corresponding 6-acetamide derivatives IIa and IIb, respectively. Chloroacetamide derivative IIa reacted with various thiols, secondary amines, potassium thiocyanate, compounds containing active methylene group,1-anilino-2,2-dicyanoethenethiolate, and o-mercatocyanopyridines to give S-alkyl, N-alkyl, thiazole, pyrrole, thiophene, and thienopyridine derivatives, respectively. Antibacterial and anti-inflammatory activities of some new pyridine derivatives were studied. Read more

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