lobna.nassr

Lobna Abdel-Mohsen Ebaid Nassr

Professor - Head Of Chemistry Department- Director of Quality Management Unit - Faculty of Science - Sohag University

Faculty of science

Address: Chemistry Department - Faculty of Science - Sohag University

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Publications Which contain the keyword: DNA interaction

Design and Development of Some Novel Metal Anil Chelates for DNA Interaction and Pharmaceutical Applications

2018-10-01 14:30:21 Keywords Development effects, Metal Anil Chelates, DNA interaction, Pharmaceutical Applications, Design,
Design and Development of Some Novel Metal Anil Chelates for DNA Interaction and Pharmaceutical Applications
Air and moisture stable coordination compounds of some first transition metals such as Cr (III), VO (II), Ni(II) and Mn(II) with newly designed tri- and tetra-dentate imine ligands (HNAP, HNPN and ESPN) were synthesized. Tridentate imine ligands (HNAP, ESAP) were synthesized by reacting 2-hydroxynapthaldehyde (HN) with 2-aminophenol (AP), whereas tetra-dentate imine ligands (HNPN and ESPN) were prepared by reacting 2-hydroxy-1-napthaldehyde ... Read more

Design, Physicochemical Studies and DNA Interaction of Some Complexes

2018-10-01 09:33:11 Keywords DNA interaction, complexes, Schiff bases, Antimicrobial activity,
Design, Physicochemical Studies and DNA Interaction of Some Complexes
In recent years, great interest has been focused on Fe(II) Schiff bases amino acids complexes as cytotoxic and antitumor drugs. Thus a series of new iron(II) complexes based on Schiff bases amino acids ligands have been designed and synthesized from condensation of 2-hydroxy-1-naphthaldehyde and 5-bromosalicylaldehyde (bs) with α-amino acids ((L-alanine (ala), L-phenylalanine (phala), L-aspartic acid (aspa), L-histidine (his) and L-arginine ... Read more

Kinetics of Alkaline Hydrolysis and DNA Interaction of Iron Complexes

2018-10-01 14:10:56 Keywords Iron Complexes, DNA interaction, Hydrolysis, Kinetics,
Kinetics of Alkaline Hydrolysis and DNA Interaction of Iron Complexes
Air and moisture stable coordination compounds of some first transition metals such as Cr (III), VO (II), Ni(II) and Mn(II) with newly designed tri- and tetra-dentate imine ligands (HNAP, HNPN and ESPN) were synthesized. Tridentate imine ligands (HNAP, ESAP) were synthesized by reacting 2-hydroxynapthaldehyde (HN) with 2-aminophenol (AP), whereas tetra-dentate imine ligands (HNPN and ESPN) were prepared by reacting 2-hydroxy-1-napthaldehyde ... Read more

Physicochemichal properties, DNA interaction, antiviral and antioxidant activities of some Amino Acid Imine Chelates

2018-10-01 13:38:05 Keywords Antiviral, Antioxidant activity, DNA interaction, amino acid, Imine Chelates, Antimicrobial activity, IR, TGA, thermodynamic parameters,
Physicochemichal properties, DNA interaction, antiviral and antioxidant activities of some Amino Acid Imine Chelates
Schiff base amino acid ligands which derived from the condensation of 3-methoxysalicylaldehyde (MS) or 4-diethylaminosalicylaldehyde (DS) with some of α-amino acids (Phenylalanine (Phe), Histidine (His), Tryptophan (Trp)) were prepared. Moreover, eleven Schiff base amino acid binary Fe(II) and Cu(II) complexes were prepared. In addition to, five ternary Cu(II) complexes which derived from the prepared Schiff base amino acid ligands as ... Read more

Kinetic study of the hydroxide ion attack on and DNA interaction with high spin iron(II) Schiff base amino acid chelates baering ONO donors

2018-09-16 13:53:29 Keywords Substituent effect, base catalyzed hydrolysis, Reactivity, reaction mechanism, thermodynamic parameters, DNA interaction,
Kinetic study of the hydroxide ion attack on and DNA interaction with high spin iron(II) Schiff base amino acid chelates baering ONO donors
Kinetic study of some novel high spin Fe(II) complexes of Schiff base ligands derived from 5-bromsalicyaldehyde and amino acids with the OH− ion and DNA has been carried out. Based on the kinetic data, the rate law and a plausible mechanism were proposed. Kinetic data of the base catalyzed hydrolysis imply pseudo first-order double stage process due to the presence ... Read more

Nano structure Iron (II) and Copper (II) Schiff base complexes of a NNO-tridentate ligand as new antibiotic agents: spectral, thermal behaviors and DNA binding ability

2018-09-16 13:40:18 Keywords TGA, NMR, IR, Calf thymus DNA, Antimicrobial activity, Synthesis, characterization, Nano particle, DNA interaction,
Nano structure Iron (II) and Copper (II) Schiff base complexes of a NNO-tridentate ligand as new antibiotic agents: spectral, thermal behaviors and DNA binding ability
Complexes of Fe (II) and Cu (II) with a tridentate Schiff base, 2-((z)-(pyridine-2-ylimino) methyl) naphthalene1-ol derived from 2-hydroxy-1-napthaldehyde and 2-aminopyridine were synthesized. Both the ligand and its complexes were characterized on the basis of microanalysis, melting point, 1H and 13CNMR, molar conductivity, thermal analysis, IR and UV/Vis spectral studies. From analytical data, the stoichiometry of the complexes was found to ... Read more

Synthesis, physicochemical studies, embryos toxicity and DNA interaction of some new Iron(II) Schiff base amino acid complexes

2018-09-16 14:36:08 Keywords Fe(II) complexes, Toxicity, DNA interaction, amino acid, Schiff base,
Synthesis, physicochemical studies, embryos toxicity and DNA interaction of some new Iron(II) Schiff base amino acid complexes
New Fe(II) Schiff base amino acid complexes derived from the condensation of o-hydroxynaphthaldehyde with l-alanine, l-phenylalanine, l-aspartic acid, l-histidine and l-arginine were synthesized and characterized by elemental analysis, IR, electronic spectra, and conductance measurements. The stoichiometry and the stability constants of the complexes were determined spectrophotometrically. The investigated Schiff bases exhibited tridentate coordination mode with the general formulae [Fe(HL)2]·nH2O for ... Read more

Design, characterization, teratogenicity testing, antibacterial, antifungal and DNA interaction of few high spin Fe(II) Schiff base amino acid complexes

2018-09-16 14:32:30 Keywords Schiff base, amino acid, Fe(II), Teratogenicity, DNA interaction, antibacterial, Antifungal, high spin, Design, IR,
Design, characterization, teratogenicity testing, antibacterial, antifungal and DNA interaction of few high spin Fe(II) Schiff base amino acid complexes
In this study, new Fe(II) Schiff base amino acid chelates derived from the condensation of o-hydroxynaphthaldehyde with l-alanine, l-phenylalanine, l-aspartic acid, l-histidine and l-arginine were synthesized and characterized via elemental, thermogravimetric analysis, molar conductance, IR, electronic, mass spectra and magnetic moment measurements. The stoichiometry and the stability constants of the complexes were determined spectrophotometrically. Correlation of all spectroscopic data suggested ... Read more

Reactivity Trends and Kinetic Inspection of Hydroxide Ion Attack and DNA Interaction on Some Pharmacologically Active Agents of Fe(II) Complexes at Different Temperatures

2018-09-16 13:59:31 Keywords Activation energy barrier, DNA interaction, Amino acids, high-spin Fe(II) complexe, Kinetic Inspection, Temperature,
Reactivity Trends and Kinetic Inspection of Hydroxide Ion Attack and DNA Interaction on Some Pharmacologically Active Agents of Fe(II) Complexes at Different Temperatures
The reactivity of few novel high‐spin Fe(II) complexes of Schiff base ligands derived from 2‐hydroxynaphthaldehyde and some variety of amino acids with the OH− ion has been examined in an aqueous mixture at the temperature range from 10 to 40°C. Based on the kinetic investigations, the rate law and a plausible mechanism were proposed and discussed. The general rate equation ... Read more

Recent advances in synthesis, characterization and biological activity of nano sized Schiff base amino acid M (II) complexes

2018-09-16 13:48:24 Keywords DNA interaction, Antimicrobial, TEM, TGA, amino acid, Azomethine, IR, NMR,
Recent advances in synthesis, characterization and biological activity of nano sized Schiff base amino acid M (II) complexes
Azomethine amino ligands derived from the condensation of 3-methoxysalicylaldehyde (MS) or 4-diethylaminosalicylaldehyde (DS) with α-amino acids (L-phenylalanine (P) and DL-tryptophan (T)) were synthesized. All ligands were analyzed by IR, 1H NMR, 13C NMR and their melting points. Interaction of the obtained azomethine amino ligands with metal salts produced novel nano sized Fe (II) and Cu (II) complexes. The isolated complexes ... Read more