khaled.mohammed

Khaled M. H. Mohammed

Lecturer - Lecturer in Physical Chemistry

Faculty of science

Address: Chemistry Department, Faculty of Science, Sohag University, Sohag, 82524, Egypt

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Publications Which contain the keyword: DNA interaction


2018-11-28 20:59:46 Keywords DNA interaction, Base-catalyzed hydrolysis, Fe(II),
Reactivity trends and kinetic inspection of hydroxide ion attack and DNA interaction on some pharmacologically active agents of Fe(II) amino acid Schiff base complexes at different temperatures
The reactivity of few novel high-spin Fe(II) complexes of Schiff base ligands derived from 2-hydroxynaphthaldehyde and some variety of amino acids with the OH− ion has been examined in an aqueous mixture at the temperature range from 10 to 40°C. Based on the kinetic investigations, the rate law and a plausible mechanism were proposed and discussed. The general rate equation ... Read more

2018-11-27 23:00:21 Keywords Embryos toxicity, Schiff base amino acid, DNA interaction,
Synthesis, physicochemical studies, embryos toxicity and DNA interaction of some new Iron(II) Schiff base amino acid complexes
New Fe(II) Schiff base amino acid complexes derived from the condensation of o-hydroxynaphthaldehyde with L-alanine, L-phenylalanine, L-aspartic acid, L-histidine and L-arginine were synthesized and characterized by elemental analysis, IR, electronic spectra, and conductance measurements. The stoichiometry and the stability constants of the complexes were determined spectrophotometrically. The investigated Schiff bases exhibited tridentate coordination mode with the general formulae [Fe(HL)2]nH2O for ... Read more

Complexation of Schiff bases incorporating of Salicylaldehyde Derivatives and Amino Acids to Copper(II) as an effective strategy for antimicrobial activity improvement, DNA Interaction and catalytic activity
Five Cu(II) complexes are tridentate Schiff bases amino acids ligands derived from condensation 3–methoxysalicylaldehyde (MS) or 4-diethylaminosalicylaldehyde (DS) with α-amino acids (L-phenylalanine(P), L-histidine (H), DL-tryptophane (T)). All ligands are analyzed by 1HNMR and 13CNMR. The investigated complexes have been prepared and characterized by elemental analysis, infrared spectra, ultraviolet-visible and thermal analysis in dynamic air atmosphere (40ml / min) at a ... Read more

Approach to Synthesis, Characterization, Antimicrobial Activities and Catalytic Activity of Some Transition Metal Complexes Containing Biologically Active Asymmetrical Tetradentate Ligands.
AIR AND MOISTURE STABLE COORDINATION COMPOUNDS OF FIRST TRANSITION METALS SUCH AS CO(II), NI(II) AND CU(II) WITH NEWLY DESIGNED SCHIFF BASE (BSIPH) INCORPORATING 5-BROMOSALICYALDEHYDE WITH ISATIN AND 4-NITRO-O-PHENYLENE DIAMINE HAVE BEEN SYNTHESIZED TO ELUCIDATE THE STRUCTURE OF METAL COMPLEXES. THEY ARE CHARACTERIZED BY ELEMENTAL ANALYSES, INFRARED, 1HNMR, 13CNMR, THERMAL ANALYSIS, UV-VISIBLE, CONDUCTIVITY AND MAGNETIC SUSCEPTIBILITY MEASUREMENTS. THE RESULTS SUGGEST THAT ... Read more

Synthesis, Characterization and Biological Studies of Some new Cr(III), Fe(III) and Cu(II) Complexes based on Multi-Substituted  Aryl Imidazole ligand
New Cr (III), Fe (III) and Cu (II) complexes with MSBB (2‐(1‐butyl‐4,5 diphenyl‐1H‐imidazol‐2‐yl)(4-bromophenol) were synthesized. The multi-substituted aryl imidazole ligand (MSBB) and its complexes were characterized by using elemental and thermal analysis, molar conductivity, magnetic susceptibility, UV-Vis spectral data, IR, and NMR. The obtained data showed that prepared complexes were 1 :1 (metal : ligand) ratio, octahedral (Oh) for all ... Read more

Synthesis, characterization, DNA cleavage and antimicrobial activity of Schiff base transition metal complexes containing heterocyclic ligand
SOME NOVEL SCHIFF BASE METAL COMPLEXES OF CU(II), CO(II), NI(II) AND FE(II) DERIVED FROM 2-AMINO-3-HYDROXYPYRIDINE AND 4-NITROBENZALDEHYDE WERE SYNTHESIZED. THESE COMPOUNDS WERE CHARACTERIZED BY ELEMENTAL ANALYSIS, MOLAR CONDUCTANCE, MAGNETIC SUSCEPTIBILITY, THERMAL MEASUREMENTS, INFRARED AND ULTRAVIOLET–VISIBLE SPECTRA. THE SCHIFF BASE AND METAL COMPLEXES DISPLAYED GOOD ACTIVITY (AGAINST THE BACTERIA, _ESCHERICHIA COLI,__SERRATIA MARCESCENCE_AND_MICROCCUS LUTEUS_, AND THE FUNGI _ASPERGILLUS FLAVUS_, _GETRICHM CANDIDUM _AND ... Read more

DNA Interaction, Antimicrobial, Anticancer Activities and Molecular Docking Study of Some New VO(II), Cr (III), Mn(II) and Ni(II) Mononuclear Chelates encompassing Quaridentate imine ligand,
DNA Interaction, Antimicrobial, Anticancer Activities and Molecular Docking Study of Some New VO(II), Cr (III), Mn(II) and Ni(II) Mononuclear Chelates encompassing Quaridentate imine ligand, Read more

Design, Characterization, DNA Interaction and antimicrobial of novel copper(II) Schiff base amino acid complexes
Five novel copper(II) complexes derived from the condensation between 5-bromosalicyaldhyde (bs) and α-amino acids (L-alanine, L-phenylalanine, L-aspartic acid, L-histidine and L-arginine) were synthesized and characterized by their elemental analyses, thermogravemetric analysis, IR, electronic spectra and conductance and magnetic measurements. Moreover, the stoichiometry and the stability constants of the prepared complexes have been determined spectrophotometrically. The Results indicated that the Schiff ... Read more

Desighn, Characterization and Biological activity of new mixed ligand transition metal complexes of glutamine, glutaric and glutamic acid with nitrogen based ligands.
A new series of Cu(II), Co(II), Ni(II) and Fe(II) ternary complexes of glutamine, glutaric and glutamic acid with imidazole derivatives have been synthesized. The nature of bonding and the stereochemistry of the complexes have been deduced from elemental analyses, infrared, electronic spectra, conductivity measurements and thermogravimetric analysis. The structure of [Co(glu)(IMI)2] and [Fe(glu)(IMI)2(H2O)2] complexes was validated using quantum mechanics calculations ... Read more

Nano sized ternary Cu(II) complexes Encompassing Salicylaldehyde Derivatives and Amino Acids as an Effective Strategy for Antimicrobial Activity Improvement and DNA Interaction
A series of ternary Cu(II) complexes encompassing ONO donor Schiff base amino acid ligands were synthesized from condensation of 3–methoxysalicylaldehyde (MS) or 4-diethylamino salicylaldehyde (DS) with α-amino acids (L-phenylalanine (Phe), L-histidine (His), DL-tryptophan (Trp)) as primary ligand and 2, 4-bipridyl (DP) as secondary ligand. All the prepared compounds were characterized by melting points, decomposition temperatures, elemental analysis, UV-Vis, IR spectra, ... Read more