Infectious Bronchitis Virus (IBV) infection poses significant challenges to poultry health and production. This study investigates the modulation of inflammatory cell death pathways in IBV-infected macrophages through inhibiting either caspases or COX-2/PGE2 pathway. We measured intracellular and extracellular viral genome loads, cell viability, apoptosis, and necroptosis after infecting cells with two disparate IBV strains, respiratory Conn A5968 and nephropathogenic DMV/1639. ... إقراء المزيد

Background: Evasion of apoptosis is an essential alteration for cellular genetic mutation. Survivin is a member of inhibitor of apoptosis protein (IAP) family. Under normal conditions, Survivin is expressed in embryonic and fetal tissues and markedly diminished in mature, differentiated adult tissues. Survivin was found to be re-expressed in multiple solid and hematological human malignant neoplasms. The purpose of this ... إقراء المزيد

Gastric-colon cancer is a complex, multi-stage disease involving deregulation of different signaling cascades. Tis study was conducted to determine the extent of apoptosis, angiogenesis, inflammation, and oxidative stress in patients with gastric-colon cancers. Plasma levels of soluble (s) Fas, bcl-2 as antiapoptotic indices; cathepsin D (CD), calpain I and II as proteolytic, apoptotic indices; nitric oxide (NO), lipid peroxides (LPER) ... إقراء المزيد