Chronic A1 and A2b adenosine receptor blockade improves diabetes and attenuates renal and cardiac histopathology in animals with the metabolic syndrome
Few therapies are known to enhance diastolic function. Systemic administration of natriuretlc peptldes (NP) improves diastolic function. However, this may be due to effects on load, rather than a direct myocardlal action. We generated mice with acar-disc-specific (a-MHC promoter) gain-of-function mutation (GoF, HCAT E974A) in the natriuretic peptide A receptor (NPRA) resulting in myocyte-specific constitutive NPRA activation. We hypothesized that ... إقراء المزيد